- Nevronale nettverksmodellar der dette kan ha relevans for teoretisk hypotesedanning og testing ad. anatomisk strukturelle, fysiske og kjemiske samspelmekanismar og intracellulære nettverksmekanismar som kan ha relevans for kvantitative og kvalitative endringar i søvn-vaken stadia samt relasjonar til depresjonstilstandar.

- Målemetodar for endringar i bestemte second og third messenger protein i aktuelle CNS avsnitt, som kan ha relevans for kvantitative og kvalitative endringar i søvn-vaken stadia.

- Genekspresjon/uttrykking av aktuelle reseptorar som kan ha relevans for kvantitative og kvalitative endringar i søvn-vaken stadia og endringar ved depresjonstilstandar. Studiar av transgene dyr, knock-out+ gen dyr (spesielt inducible knock-outs) samt dyremodellar for bestemte søvnendringar og depresjon.

- Endring i gen- og protein utrykk etter bestemte søvnendringar som ved søvnmangel (søvndeprivasjon) og søvnforskyvning (som skiftarbeid og jet-lag).

- Endring i gen- og protein utrykk etter /under ulike cellulært stressende situasjoner både fysisk og psykisk stress (MR-rutine dvs. sterkt megnetfelt samt RF-bølger og dykk-/hyperbar eksponering).

REVIEWER I INTERNASJONALE JOURNALER

1997 Reviewer in Sleep Research Online

2003 Ad hoc reviewer in Psychopharmacology

2006 Ad hoc reviewer in Brain Research Bulletin

2007 Ad hoc reviewer in Journal of Chemical Neuroanatomy

2007- Reviewer for Bioingeniøren, Norwegian Biomedical Scientific Journal

2018 Ad hoc reviewer for Journal of Proteomics

2021 Ad hoc reviewer for Molecular Neurobiology

PEDAGOGISK RØYNSLE

1. 1990-93, 1997-98 Fysiologi, kursundervisning av stud.- med., odont. og real. = *, 3 veker/år (5 i 91).

2. 1991-93 Fysiologisk metodikk kurs/foreles./eks., B262. odont. and mat.nat. stud. = #, hov.fagnivå, 1 veke/år.

3. 1991-92 Høgskulelektor 50% Fysiologi/anatomi for sjukepl. v/Haukeland sjpl.skule. 60 t forlesn.. (180 t totalt kurs) per undervisningssemester. Totalt 120 forelesingstimar, i tillegg repetisjonskollokvier, eksamensoppg. m/fasit og sensur (ca. 120 stud. pr/år).

I fireårsstillinga som universitetsstipendiat er det 1 år i pliktig undervisning.

4. 1997-98 I stillinga som 1. amanuensis er det 25% undervisningsplikt der eg har hatt kurs, forelesningar og eksamen for gruppene * og # sjå pkt. 1 og 2 over.

5. 1998-2001 I stillinga som NFR postdoktor har eg og hatt kurs, forelesningar og eksamen for gruppene * og # sjå pkt. 1 og 2 over.

6. 2002- Førsteamanuensis, HiB, Fysiologi, anatomi og histologi. Totalt 120 forelesingstimar og 2 veker lab. kurs, i tillegg oppgåveløysing, datastøtta og interaktiv læring, repetisjonskollokvier, eksamensoppg. m/fasit og sensur (ca. 40 stud. pr/år, så 50-60 studs. etter 2015). Biokjemi/cellebiologi/molekylærbiologi 40 forelesingstimar og 2 veker lab. kurs, i tillegg oppgåveløysing, datastøtta læring, repetisjonskollokvier, eksamensoppg. m/fasit og sensur (ca. 40 stud. pr/år), etter 2015 ca 60-70 stud./år.

Vitskapleg rettleiing og sensur av forskningsoppgåver på bachelor, master og dr. gradsnivå. Utfyllande på bachelorvivå – sjå pkt. G Annan publikasjonstype under publikasjonsliste

1. 1999-2001 Co-Supervisor/Medrettleiar for hovedfagsstudent Eldbjørg Fiske, hovudoppgåve trykt, Cand. Scient. Eksamen 20 juni 2001

2. 2002-2023 Supervisor/Rettleiar for hovedprosjekt studentar, avsluttande FoU-bachelor oppgåver (ca.120 studentar, 50 oppgåver, ca. 100 studentar, 50 utland) ved Høgskolen i Bergen internt, regionale, nasjonale og internasjonale FoU-aktørar som Haukeland Universitetssykehus, Rogalandsforskning, Harvard Medical School, Harvard University, Childrens Hospital, Boston, USA, Boston University, Boston, USA, Science Research Institute (SRI), San Franscisco, USA, Oetwoes Lorand University Budapest, Ungarn og University of Pennsylvania, USA. Oppgåver, år og kandidatar sjå i slutten av dokumentet under Publikasjonar G. Annan publikasjonstype, Other publications I.

3. 2003-2005 Supervisor/Rettleiar ”Appoint to the Doctoral Committee” for PhD-student Marta Helliesen ved Union Institute and University, Cincinnati, Ohio, USA.

4. 2004 Supervisor for ERASMUS-students, Pamela Shild og Oliver Ging, Institute of Technology, Carlow, Irland, ”thesis projects” ca. 6 mndr. på eitt av mine forskningsprosjekt der genekspresjon og tolking av data inngår.

5. 2007 Sensor (ekstern) Mastergrad, Cand. Scient. Rakel Brendsdal Forthun, A phosphoproteomic study of the Theophylline-Valproic Acid-All-trans Retinoic Acid combination therapy in the Brown Norwegian Myeloid Leukemia rat model.Universitetet I Bergen, 5 December, 2007.

6. 2007 Sensor (ekstern) Mastergrad, Cand Scient. Sigrun Margrethe Hjelle, Expression and function of p53 protein isoforms in acute myeloid leukemia. Universitetet I Bergen 17 December, 2007.

7. 2008 Sensor (ekstern) Mastergrad, Cand Scient. May Lillian Ofte, Effect of Antidepressant Treatment on the Expression of LTP-associated MicroRNAs. Universitetet i Bergen, 16 June, 2008.

8 2008 Supervisor for IAESTE-student Cuc Quynh Nguyen Truong, 2,5 months August – October on my ongoing R&D-projects.

9. 2009 Sensor (ekstern) Mastergrad, Cand Scient. Henriette Aksnes, Time-laps imaging of Arc/Arg3.1 protein degradation in hippocampal neurons using the novel photoconvertible fluorecent protein Dendra 2. Universitetet i Bergen, 22 June, 2009.

10. 2009 Sensor (ekstern) Mastergrad, Cand Scient. Birgitte Berentsen, microRNA-34a Functions in Long-Term Potentiation in the Dentate Gyrus of the Anesthetised Rat. University of Bergen, 23 June, 2009.

11. 2010 Supervisor for IAESTE-student Seok-Min Hong, 3 months January - March on my ongoing R&D-projects.

12. 2011 Supervisor for IAESTE-student Michael Sandmann, 3 months January - March on my ongoing R&D-projects.

13. 2011 Sensor (ekstern) Mastergrad, Cand Scient. Eva Rønneseth. Akutt intermitterende porfyri. Kartlegging av funksjonelle og termodynamiske eigenskapar av hydroksymetylbilan syntase og utvalgte mutantar. Institutt for samfunnsmedisin, Universitetet i Bergen, 8 juni 2011.

14. 2011Sensor (ekstern) Mastergrad, Cand Scient. Elise Aasebø. Aproteomic study of Cerebrospinal fluid in relation to biomarker discovery and verification in Multiple Sclerosis, with emphasis of the effect of pre-analytical factors. Department of Biomedicine, University of Bergen, June 7th, 2011.

15. 2011Sensor (ekstern) Mastergrad, Cand Scient. Yngvild Bjørlykke. Proteomics in Cerebrospinal fluid, Finding proteins highly enriched in CSF, protein influenced by rostral-caudal gradient, and biomarker verification in Multiple Sclerosis. University of Bergen, June 7th, 2011.

16. 2012 Supervisor for ERASMUS-student Britt Deckers, 3 months, February-April on my ongoing R&D-project.

17. 2012 Supervisor for ERASMUS-student Rico Zimmermann, 4 months, February-June on my R&D-project.

18. 2012 Sensor (ekstern) Mastergrad, Cand Scient. Marianne Gravås. Validation of the Cardioprotective Properties of Two Humoral Factors Released into the Effluent of Ischemic Preconditioned Rat Hearts. Department of Biomedicine, University of Bergen, May 31st, 2012.

19. 2013-2014 Supervisor for IAESTE-student Ana Carasco Duran, 12 months, Oct. 2013- 2014 and as EU-grant student.

20. 2013-2014 Supervisor for NAV-training position/post doc. PhD Dola Sinha Roy, from Nov. 2013- to dd - max. one year formally, to dd practically.

21. 2013-2015 Supervisor for Master in Innovation and Entrepreneurship-student Beate Kluge, siv. Ing. And Head engineer at Haukeland University Hospital and University of Bergen, joint master between UiO and BUC/HiB. Master thesis: Implementering av ny teknologi i offentlige forsknings- og helsemiljø med impedansspektroskopi som eksempel.

22. 2015 Supervisor for ERASMUS-student Charlotte Blancke, 3 months, February-April on my ongoing R&D-project.

23. 2015 Supervisor for ERASMUS-student Anja Meierhenrich, 5 months, March-August on my ongoing R&D-project.

24. 2015-2016 Supervisor for Master Kristian Svinø Hestetun, Master’s thesis in Software Engineering at Department of Computing, Mathematics and Physics, Bergen University College and Department of Informatics, University of Bergen.

25. 2015-2016 Co-supervisor for Master Markus Lippert Karlsen, Master’s thesis in Software Engineering at Department of Computing, Mathematics and Physics, Bergen University College and Department of Informatics, University of Bergen.

26. 2017 Supervisor for “Practicum” work and thesis for Allina Ibbeken, Automatic cell detection with convolutional networks to examine cellular reactions to stress exposure. Prakticum and the cellular work at the Univerity of Lubeck and software related analyzis at in Software Engineering at Department of Computing, Mathematics and Physics, Bergen University College, Bergen, Norway

27. 2019 Sensor (ekstern) Mastergrad, Cand Scient., Susanne Benjaminsen, Development of an in vivo selectionbased model system to stydy PDAC liver colonialization. In obese and non-obese microenvironment. Department of Biomedicine, University of Bergen, June 27^th, 2019

28. 2020 Sensor (ekstern) Mastergrad, Cand Scient., Marianne Stokka, Microfluidic-based biomimetic models for toxicological and therapeutic testing of nanoparticles. MSc, Nanoscience, University of Bergen, October, 2020

29. 2018-2022 Co-supervisor for NN, PhD Research Fellow, Dept. of Computing, Mathematics and Physics, Western Norway University of Applied Sciences, Bergen, Norway.

30 2023-2024 and collab. to dd Supervisor for “Practicum” work and thesis for Leandra Alicia Griebel, Bachelor in Health Sciences and Technology, Eidgenoessiche Technische Hochschule Zurich (ETH), Zurich, Switzerland.

POPULÆRVITSKAPLEG AKTIVITET (35)

2021 Forskningsdagene, planlagt tre skolebesøk om søvn, døgnrytme, hukommelse og læring.

2020 Forskningsdagene Idrettswebinar. Optimal Sleep and Circadian Rhythm – a Prerequicite for Improved Memory and Learning https://www.youtube.com/watch?v=hOB4o3ucZJI

2020 Forskningdagene Ung dag 2 Aulaen, Universitetet i Bergen, Betydning av søvn og døgnrytme for læring og hukommelse se ca 18 min ut i webinaret; https://www.youtube.com/watch?v=xA4XK-REi7E&t=2576s

2015 Biolas - Bioingeniørstudentenes forening ved HiB, Søvn = læring, hukommelse og helse - Søvnmangel = dårlig læring, hukommelse og helse pga. cellestress? Foredrag på HiB/BUC CamPus Kronstad, Bergen.

2014 Tekna – innvitert foredrag, utsatt

2012 Søvn påvirker hukommelse og helse - Kan cellene våre bli stresset av søvnmangel? - Kan det måles? Populærvitenskapelig foredrag på Biblioteket på AI/Nygård, Høgskolen i Bergen, 12.12.2012.

2011 Slår alarm om overtid på Rikshospitalet, Havner man på Rikshospitalet etter en ulykke kan sykepleieren ha jobbet 17,5-timersskift i flere dager. Dabladet på nett 08.03.2011

http://www.dagbladet.no/2011/03/08/nyheter/adecco/innenriks/arbeidsliv/politikk/15680141/

2010 Radio Norges vitenskapsprogram Kosmo ved Marianne Moe del 1 søndag 30.05.2010 og del 2 og 3 søndag 06.06.2010. Lydfiler tilgjengelig på forespørsel.

2010 Nyskjerrigper, NFR, skoleoopppgave, Lægreid skole; Test din reaksjonsevne; http://nysgjerrigpermetoden.no/pdf/1507_2010.05.31.pdf

2008 Søvnmangel - kan det stresse cellene våre? VilVite Bergen Science Centre, PopVit-foredragserien, foredrag 27.01.08

http://www.vilvite.no/index.php?action=static&id=241

2007 Nattarbeid på helsa løs, Aftenbladet (tidligere Stavanger Aftenblad?).07.11.07, intervju.

http://web3.aftenbladet.no/energi/arbeidsliv/article549381.ece

2007 Stress på cellenivå, Ukens ugle i Bergens Tidende, 05.10.07

2007 Søvnløshet er verst for B-mennesker, kommentar, Mozon, 17.04.07

http://mozon.no/andre-saker/saker/-+s%F8vnl%F8shet+verst+for+b-mennesker/art377085.html

2007 In å sove alene, Adresseavisa nettutgave, 10.04.2007

http://www.adressa.no/forbruker/sexogsamliv/article841213.ece

2006 Helsefaglig nattarbeid, intervju, Frifagbevegelse.no, 19.10.2006

http://www.frifagbevegelse.no/arbeidslivet/norge/article2358582.ece

2006 Sunn helse og skiftarbeid, Mozon, 20.09.06

http://www.mozon.no/php/art.php?id=351849

2006 Skiftarbeid kan gi kreft, kommentar, VG-nett, 20.09.06

http://www.vg.no/pub/vgart.hbs?artid=131106

2006 Er nattlige forhandlere som promillekjørere? i Lederne kommentert på lederplass, ansv. Redaktør, 01.09.06

http://lederne.no/files/Lederne3-2006_1.pdf

2006 Forsker advarer mot nattlige forhandlinger, Journalisten, 23.06.06

http://www.journalisten.no/story/39428

2006 Invitert gjest i studio til NRK1s Balsam for å snakke om bla. søvn, søvnmangel og skifarbeid, 35 min, 27.04.06

2006 Intervju om søvn, I studio 30 min i Radio 1, 20.04.06

2006 Livsviktig søvn? Forskning. no, web-publikasjon 19.04.06

https://forskning.no/stress-partner-forebyggende-helse/livsviktig-sovn/1013549

2006 Så mye søvn trenger du, TV2 Nettavisen, web-publikasjon 19.04.06

http://pub.tv2.no/nettavisen/side2/helse/article613647.ece

2005 Høy pris for skiftarbeid, intervju, Bergens Tidende, 27.12.05

2005 Når barna ikke får nok søvn, Forskningsdagene, annonsebilag fra Norges Forskningsråd, s.11.

http://escenicpublish.avis.dn.no/multimedia/archive/00014/20_09_2005__Norges_f_14168a.pdf

2005 Søvnforskerne fra Seljedalen, Sydvesten, 03.10.05

http://www.sydvesten.no/05-36/Sak05103.html

2005 Forskningsdagene, Foredrag: Søvn og stressa celler, 24.09.2005

http://www.hib.no/forskningsdagene/foredrag.html

2005 Forskningsdagene, Skoleprosjekt, Seljedalen skole: Får vi nok søvn? August-September og presentasjon 23.10.2005

http://www.hib.no/forskningsdagene/skoleprosjekt/program.htm

2004 Søvnforskere reagerer, intervju, Dagsavisen, 22.10.2004

http://www.dagsavisen.no/innenriks/article1298289.ece

2004 Om søvnsøvnmangel i vår tid. Aftenposten Aften, intervju i temaartikkel, oktober 2004

2004 Tropevarme og søvn, intervju i temaartikkel, Dagbladet, 11.08.2004

2004 Uten søvn blir du syk. Nettavisen, web-avis, 22.06.2004

http://pub.tv2.no/nettavisen/helse/article243223.ece

2004 Søvn - fra stress til sykdom? Forskning. no, web-publikasjon, 22.06.2004

https://forskning.no/partner-arbeid-forebyggende-helse/sovn---fra-stress-til-sykdom/1051636

2004 Sover du? Eller er du død? Startsiden, magasinet, web-portal, 21.01.2004

http://magasinet.startsiden.no/magasinet/content/view/full/39387

1999 Søvn og døgnrytmer, intervju I NRK P3 Mamarazzi

ADMINISTRATIVE STILLINGAR - LEIAR - VERV- OPPGÅVER

2019- Leder Bergen CellStress, Tissue Engineering and Simulation in Biomedicine – BeCSTESim in Biomedicine, ISKB

https://www.hvl.no/forsking/gruppe/bergen-cellstress/ og engelsk https://www.hvl.no/en/research/group/bergen-cellstress/

2017-2019 Leder av FoU-gruppen BIOMARG ved Bioingeniørutdanningen, IBK, FIN, HVL

2002- Ledet egen Cellestress (fra søvnmangel til MR og hyperbar eksponering) FoU-gruppe f.o.m. 2002-2019, IBK så ISKB, FIN, HVL

2015 Medlem i Strategiplan utvalg ad Profilering og omdømme for Høgskolen i Bergen.

2011-15 Avdelingsråd, valgt representant frå dei faglege tilsette ved Avdeling for Ingeniørutdanning, Høgskolen i Bergen.

2010 - 2020 Forskerforbundet, Leder i klubbstyre, Avdeling for ingeniørutdanning, Høgskolen i Bergen, nå FIN, HVL.

2008-2010 Forskerforbundet, Nestleder i Lokallaget ved Høgskolen i Bergen

2007 Representant i Samarbeidsutvalget ad Proteomikklaboratoriet, samarbeidavtale med Molekylærbiologisk Institutt, UiB og AKB-instituttet HIB.

2007 Avdelingsråd, valgt representant frå dei faglege tilsette ved Avdeling for Ingeniørutdanning, Høgskolen i Bergen.

2007 Høgskulestyre, valgt vararepresentant fra dei faglege tilsette, Høgskolen i Bergen.

2006 Forskerforbundet, nestleder i klubbstyre, Avdeling for ingeniørutdanning, Høgskolen i Bergen

2005-2023 Forskningsleder for Cellestress-FoU/N-gruppen ved Bioingeniørutdanningen, Avdeling for ingeniørutdanning, Høgskolen i Bergen

2004 IKT-utval, medlem, Avdeling for ingeniørutdanning, Høgskolen i Bergen

2003-2006 Forskerforbundet, medlem i klubbstyre, Avdeling for ingeniørutdanning, Høgskolen i Bergen

2002- Ledet egen Cellestress FoU-gruppe f.o.m. 2002-2019

2001 Forskningskoordinator, Stiftelsen Universitetsforskning Bergen (Unifob)

2001 Valgt representant til fakultetsstyre ved Det medisinske fakultet, UiB

1999 Initiativ til organisering og koordinering av Symposium, Focus Group og Workshop på World Federation of Sleep Research Societies, Third International Congress, Dresden, 1999

1997-98 Koordinerande timeplanarbeid for preklinisk undervisning, UiB

1997 Initiativ til og fagleg og administrativt ansvar for internasjonalt møtet arrangert 6-7 Desember 1997 ved Søvnforskingslaboratoriet ved Fysiologisk Institutt, Universitetet i Bergen: ”In vivo Microdialysis in The Central Nervous System in Animals and Humans”.

1993 Medlem i fakultetsstyre og fakultetsråd ved Det medisinske fakultet, UiB

1992 Leiaransvar for søvnforskingslaboratoriet v/Prof. Ursin sitt 6 mnd. utanlandsopphald s.å.

1991-1993 Medlem i instituttstyre og instituttråd ved Fysiologisk institutt ved UiB

1991-1992 Medlem i kollegierådet ved UiB

FORSKINGSOPPHALD:

1992 ved Institutionen for Farmakologi, Karolinska Institutet, Karolinska Sjukhuset, Stockholm invitert av Prof. dr. med. Urban Ungerstedt.

Nordisk forskerutdanningsakademi stipend, 23 600 NOK

1995-1997 ved Harvard University, Harvard Medical School, Dept. of Psychiatry, Lab. of Neuroscience, Brockton VA Medical Center, Psychiatry invitert av Prof. og Director Robert W. McCarley, M.D.

Fulbright Research Fellow, 80 000 NOK

NFR-forskningsopphald, 75 000 NOK

Norge-Amerikaforeningen, 35 000 NOK

1998-2000 ved Harvard University, Harvard Institute of Medicine, Dept. og Neurology, Boston, USA

Beth Israel Hospital, invitert av Prof. og Chairman Clifford B. Saper, M.D.

Visiting Associate Professor/NFR-postdoktor

FORSKNINGSTEKNIKKAR

Arbeidspraksis:

Operasjonsteknikkar - stereotaktisk operasjonsteknikk rotte og katt.

Smertefysiol. teknikkar - "Hot-plate test" smerteterskeltest med stigande eller konstant temperatur,

kjenneteikna av eit kort fasisk smertestimulus

- "Tail-flick test" kjenneteikna av eit kort fasisk smertestimulus

- Formalin test smerteterskeltest der stimulus varer lenger og tidleg fase truleg er direkte kjemisk stimulering av nociceptorar medan sein smerte fase truleg skuldast ein inflammatorisk prosess

Genomikkkurs med praktiske øvingar, fleire, ved Nasjonal FUGE-teknologiplatform for genmikroarray ved Universitetet i Bergen/Helse Bergen/Vest

Proteomikkkurs med praktiske øvingar, fleire, ved Nasjonal FUGE-teknologiplattform ved Universitetet i Bergen

Bioinformatikkkurs med praktiske øvingar og eigne data, Norwegian Microarray Consortium, Computational Biology unit and Bergen Center for Computational Science, University of Bergen

KURS OG ETTERUTDANNING

25 vekttal tilsvarar over 1 års arbeid, godkjente dr. gradskurs ved UiB, inkl. 2 møter m/poster og 1 forskn. opphald.

1985 "European Training Program Course on Basic Methods in Brain and Behaviour Research in Animals (11 dagar) Skriftleg oppgåve 14 s, karakter 2.1, 3 vekttal

Institutt for Fysiologisk Psykologi, UiB. Dr. Robert Murison

1987 "Legers videre og etterutdannelseskurs nr. 570 - nyere synspunkt innen nevrobiologi" (4 dagar) 1 vekttal

Fysiologisk institutt, UiB. Prof. dr. philos. Karen B. Helle

1988 "Kurs i genteknologi" (5 dagar)

Felleslaboratorium for bioteknologi, UiB. Prof. dr. med. Kjell Kleppe, dr. philos Dag Helland, dr. philos. Anders Fjose.

1988 "Kursus i gensplejsning" (10 dagar), 6 s rapport

Teknologirådets Gensplejsningsgruppe, Danmarks Tekniske Højskole. Dir. dr. med. Claus Christiansen

Forbruker og administrasjonsdept. stipend, 25 000 NOK

1990 "Toksikologi" forsker-/videreutdanningskurs (10 dagar) 2 vekttal

Noregs veterinærhøgskole arr. HEMIL-programmet: "Helse og miljøforurensning" NAVF, NTNF og NLVF. Prof. Erik Dybing.

1990 "Kurs i nevrobiologi - BZ352" (5 veker) 5 t skr. eks. kar. 2.1, 5 vekttal

Nevrofysiologisk institutt, Universitetet i Oslo (UiO)

NAVF/NFR Post doc/Forsker Ph.D. Joel C. Glover

1991 "Farmakologi - K258a og b" mntl.eks. kar 1.8, 4 vekttal

Institutt for farmakologi og toksikologi, UiB, Haukeland sjukehus. Prof. Ph.D. Ronald R. Scheline.

1991 "Medisin og forskning" hovedemner: molekylærmedisin, forskerutdanning, den medisinske forsknings utfordringer (10 timar)

Forening for leger i vitenskapelige stillinger. Prof. dr. med. Dagfinn Øgreid.

1991 "Legers videre og etterutdannelseskurs nr. 876 - cellulær signaloverføring" (4 dagar) 1 vekttal

Biokjemisk institutt, UiB. Prof. dr. med. Holm Holmsen

1991 "Seminar i cellefysiologi" 16 timar

Fysiologisk institutt, UiB. Prof. dr. philos. Gulborg S-H Søvik

1992 "Legers videre og etterutdannelseskurs nr. 907 - nyere aspekter av neurotransmisjon i sentrale og perifere systemer" (3 dagar) 1 vekttal

Fysiologisk institutt, UiB. Prof. dr. philos. Gulborg S-H Søvik

1992 "Microdialysis seminarium" (2 dagar)

Nevrofysiologisk institutt, UiO og CMA/Microdialysis AB

Prof. dr. med. Terje Sagvolden, Prod. man. Ph.D. Agneta Eliasson

1997 Society for Neuroscience: Advanced Molecular Techniques for Neuroscience, Special Course Two

2004 Course in Microarray Data Analysis – theoretical and practical course - one week

Norwegian Microarray Consortium, Computational Biology unit and Bergen Center for Computational Science, University of Bergen

2004 User Course in Microarray Technology and Applications - theoretical and practical course - one week

Norwegian Microarray Consortium, a National FUGE-Platform for DNA MicroArray Technology, University of Bergen

2005 Course in Bioinformatics for Proteomics - a theoretical and practical course - one week

Proteomic Unit, PROBE is a core facility for proteomics supported by Norges forskningsråd (the FUGE programme) and the University of Bergen.

2005 Ideutviklingsseminar, Forretningsplan skriving for konkret prosjekt - Pattern Solutions, Høgskoletake-off, tre dager, en uke og en-dags oppfølgingsmøte, et samarbeidsprosjekt mellom

Norges Tekniske-Naturvitenskapelige Universitet (NTNU), Innovation Net og Norges Forskningsråd

2006 Course in proteomics, PROBE-kurs, Proteomic Unit, PROBE is a core facility for proteomics supported by Norges forskningsråd (the FUGE programme) and the University of Bergen.

2006 Advanced Microarray Analysis Course I – theoretical and practical course - one week

Norwegian Microarray Consortium, Computational Biology unit and Bergen Center for Computational Science, University of Bergen, 4-8 December 2006.

2007 Advanced Microarray Analysis Course II - worked on own genemicroarray data - Norwegian Microarray Consortium, Computational Biology unit and Bergen Center for Computational Science, University of Bergen, June, 2007.

2008-2017 Several courses in Proteomics, Systems Biology at PROBE, National Proteomic Unit, Bergen, Norway

2014-2015 Educational Leadership Program, Bergen University College, Bergen, Norway

2019 ELMED219 19V / Kunstig intelligens og beregningsorientert medisin/ Artificial intelligence and computational medicine, 6 ECTS

2020-2021 Forskningsledelse på Vestlandet, UiS og HVL

MEDLEM I VITSKAPLEGE SELSKAP

1. Norwegian Physiological Society

2. Scandinavian Physiological Society

3. Scandinavian Society for Sleep Research

4. European Sleep Research Society

5. European Neuroscience Association

6. Society for Neuroscience, USA

7. Sleep Research Society, USA

2005 Benzonsymposium nr. 52, Cellular responses to DNA damage, Copenhagen, Denmark */p

2005 Interim Congress of World Federation of Sleep Research and Sleep Medicine Societies (WFSRSMS), New Delhi, India */p - not attended

2005 Bergen Teknologi Overføring (BTO)-møtet, Bioscience and commercialization, Bergen, 2005 */p

2006 European Sleep Research Societies, Insbruck, */p

2006 BTO-møtet, Bioscience and commercialization, Bergen, */p

2007 Den 12. Nordiske Søvnkonferansen, Nordic Society for Sleep Research, */^M

2007 World Federation of Sleep Research Societies, Internastional meeting, Cairns Australia, */p.

2007 Neuroscience, International meeting, San Diego, USA, */pp

2008 19th Congress of the European Sleep Research Society, 9-13 September 2008, Glasgow, UK */m, s

2009 Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

2010 European Sleep Research Societies, Lisboa, */s

2011 APSS/Sleep, American Sleep meeting, Minneapolis, USA, */p

2011 20^th International Symposium on Shiftwork and Working Time – Biological mechanisms, recovery, and risk management in the 24h society, June 28-July 1, 2011, Stockholm */m, s.

2012 APSS/Sleep, American Sleep meeting, Boston, USA.*/p

2013 APSS/Sleep, American Sleep meeting, Baltimore

2014 Gordon Research Conferences, Sleep Regulation and Function, March 16-21, 2014, Galveston Texas, USA */m, p

2016 Winter Meeting of the Norwegian Physiological Society, Geilo, January 28-31, 2016.

2017 Sleep Boston, 31st Annual Meeting of the Associated Professional Sleep Societies (APSS) June 3-7, 2017.

2017 World Sleep 2017. A joint congress of World Association of Sleep Medicine (WASM) and World Sleep Federation (WSF) Praha, Czech Republic, Oct.7-11, 2017.

2018 Neuroscience, International meeting, San Diego, USA, */p

2020 APSS/Sleep, American Sleep meeting web-meeting, Aug. 27-30.

2021 APSS/Sleep, American Sleep meeting web-meeting, June 10-13.

2022 World Sleep Meeting, March 11-16 in Rome, Italy */p

2023 European Sleep Research Societies 1^st e-meeting */p

2024 Sleep Europe 2024 - 27th Congress of The European Sleep Research Societies, 24-27 Sept. Seville, Spain */p/c and Co-Chair.

LISTE OVER FOREDRAG

1992 Spinale mekanismar i deaktivering og søvn. Antidepressivas verknad på frisetting av serotonin målt med mikrodialyse. Nordisk seminar. Smertegruppa ved Fysiologisk institutt, UiB og ASTRA Pain Control AB.

Universitetet i Bergen, Noreg

1995 Spinal modulation of ascending sensory information: Effects in sleep and waking. Symposieinnlegg World Federation of Sleep Research Societies, Second International Congress, Nassau, Bahamas

1995 Modulatory role of the descending serotonergic system in sleep and waking. Symposieinnlegg

The structure and function of the spinal cord, Nordic Network in Neurostereology. University of Bergen, Norway

1996 Simultaneous recording of sleep-wake stages, and alteration in brain neurotransmitters during sleep and wakefulness, measured by the microdialysis method.

Woodstock Academy, Department of Psychology, Woodstock, Connecticut, U.S.A.

1997 The serotonergic system and behavior: changes related to sleep-wake states and depression.

Harvard University, Harvard Medical School, Neuroscience Basics of Psychopharmacology, course lecture for M.Ds in last year recidency, psychiatry.

1997 Modulatory role of the descending serotonergic system in sleep and waking. Muntlig presentasjon.

Nordic Sleep Congress, Scandinavian Societies for Sleep Research, Bergen, Norway

1997 Serotonin and GABA inhibit dorsal raphe nucleus and increase REM sleep as revealed by microdialysis.

Nordic Sleep Congress, Scandinavian Societies for Sleep Research, Bergen, Norway

1997 A microdialysis study of neurotransmittors/neuromodulators regulating dorsal raphe nucleus activity:

serotonin, GABA, and adenosine.

Multi-Site Training Program for Basic Sleep Research by Sleep Research Society (US); Critical Analysis of The Role of Molecular Biology in Sleep Research at UCLA Lake Arrowhead Conference Center, LA,CA, USA.

1997 A microdialysis study of neurotransmittors/neuromodulators regulating dorsal raphe nucleus activity:

serotonin, GABA, and adenosine.

In vivo Microdialysis in The Central Nervous System in Animals and Humans. Internasjonal meeting

Sleep Research Laboratory, Department of Physiology, University of Bergen, Norway

1999 Raphe nuclei and the ventrolateral preoptic nucleus. Multisite SCORE-NIH grant-group meeting, Harvard Medical School, Harvard University.

Invited

1999 Basic regulatory mechanisms of the serotonergic system in sleep and depression.

Conference sponsored by Sleep Disorders Division at Brigham and and Women’s Hospital, Boston, USA

Invited

1999 Basic Sleep Research - Glimpse of Past, Present and Future.

Sleep-Wake Disorders Canada (SWDC) - Ottawa-Hull Chapter’s Capital Sleep Conference, Ottawa, Canada

Invited Keynote speaker

1999 World Federation of Sleep Research Societies, 3rd International Meeting, Dresden, Germany

1999 Basic Sleep Research - Glimpse of Past, Present and Future.

Bio Med Camp, Haukeland sykehus, Unge Forskere, Universitetet i Bergen, Invited (I)

2000 Basic Sleep Research - Glimpse of Present, Latest Hot News and Future.

Bio Med Camp, Haukeland sykehus, Unge Forskere, Universitetet i Bergen, I

2001 Raphe nuclei and the ventrolateral preoptic nuclei, University of Sao Paulo, Brasil, Invited

2001 Role of serotonin in REM sleep mechanisms - preclinical evidence.World Federation of Sleep Research Societies, 4rd International Meeting, October 21-26, Punta del Este, Uruguay, Invited as Symposium speaker

2001 Basic Sleep Research - Glimpse of Latest Hot News and Future perspective.

Bio Med Camp, Haukeland sykehus, Unge Forskere, August, Universitetet i Bergen, I

2001 Søvn og biologiske rytmer, Navalmedisin, Sjøkrigsskolen, Håkonsvern, Bergen

2002 Basic Sleep Research - Glimpse of Latest Hot News and Future

Bio Med Camp, Haukeland sykehus, Unge Forskere, August, Universitetet i Bergen, I

2002 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2002 Normal søvnfysiologi hos barn og voksne, Norsk Epilepsiselskap, Kristiansand, I

2003 Søvn og biologiske rytmer, Radiologisk seksjon, Kirurgisk institutt, Haukeland Universitetssykehus, Bergen, I

2003 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2003 Søvn hos barn og unge, Lysekloster barneskule, Bergen

2004 Statoil, konferanse om skiftarbeid og helse, Oslo, I

2004 Sleep, Alertness and Fatigue, Education in Recidency by American Academy of Sleep Medicine, Radiologisk seksjon, Kirurgisk institutt, Haukeland Universitetssykehus, Bergen, I

2004 NOPEF, HMS-konferanse, Søvn, skiftarbeid og helse, Stavanger, I

2004 Skiftarbeid og ulykker, Temaseminar HMS Petroleum, UiB/Unifob, Bergen, I

2004 Sleep, Alertness and Fatigue, Education in Recidency by American Academy of Sleep Medicine, Anestesileger, Kirurgisk institutt, Haukeland Universitetssykehus, Bergen, I

2004 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2005 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2005 Turnusarbeid – Søvn og biologiske rytmer, Kurs, Bioingeniørfaglig institutt, Lokal fagkomite i Bergen, I

2006 Sleep, Alertness and Fatigue in Health Care Settings, Bioingeniørfaglig institutt, Bergen I, 22.02.06

2006 Nyere forskning og diagnostikk - bruk av molekylærbiologiske teknikker, MOL 100, Universitetet i Bergen 24.04.06

2006 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I, 04.05.06

2006 Søvn, skiftarbeid og uønskede hendelser, Olje og Anleggskonferanse, EL og IT-forbundet, Bergen Kongressenter, I, 28.09.06

2006 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I, 26.10.06

2007 Differentially Expressed Proteins after Sleep Deprivation, Bergen

Nordic Sleep Meeting, Scandinavian Societies for Sleep Research, Bergen, Norway

2007 Nyere forskning og diagnostikk - bruk av molekylærbiologiske teknikker, MOL 100, Universitetet i Bergen 11.04.07

2007 Nok søvn - avgjørende for prestasjon, sikkerhet og velvære, Idealforum for å fremme dialogen mellom alle som kan bidra til en bedre folkehelse, Stavanger, I, 13-14.09.2007, utsatt av arrangør.

2008 Glasgow, ESRS symposium chaired and talk

2009 Bergen, Proteomics meeting, talk and poster.

2010 Lisboa, ESRS oral session.

2011 Minneapolis, APSS/US-sleep meeting, poster.

2011 Stockholm, Sleep and stress, oral session.

2012 Boston, APSS/US-sleep meeting, poster.

2013 Baltimore, APSS/US-sleep meeting

2014 Proteomic Changes in Human Blood Serum after Sleep Deprivation. Gordon Research Conferences, Sleep regulation and Function, Galveston Texas, March 16-21, 2014. Invited talk.

2017 SOVNOs Nasjonale møte på Solstrand, * title talk. Serum proteomics and sleep deprivation www.sovno.no

2019 SOVNO Nasjonale møte på Solstrand, * title talk. Saliva proteomics and sleep deprivation

2023 SOVNO Nasjonale møte på Solstrand, * title talk. Human serum proteomics reveal molecular signature after sleep deprivation at night.

2025 SOVNO Nasjonale møte på Solstrand title talk: Human serum proteome profiling after 6 hours of sleep deprivation at night

PUBLIKASJONSLISTE

Søk gjerne Bjorkum i National Library of Medicine, PubMed; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?otool=bibsys&holding=inouolib

OVERSIKT OVER VITSKAPELEGE ARBEID

30 trykte vitskaplege artiklar inklusive oversiktsartiklar med referee-tjeneste sjå pkt. A og C

(27 originalartiklar, 8 som førsteforfattar)

A. Originale vitskaplege publikasjonar i internasjonale tidsskrift med referee-tjeneste (27).

1Bjørkum, A.A. and Berge, O.-G. The relative contribution of ascending and descending serotonergic pathways in p-chloroamphetamine induced antinociception. Pharm. Biochem. Behavior, 1988, 31; 135-140

2Bjørkum, A.A., B. Bjorvatn, D. Neckelmann and R. Ursin. Sleep effects following intrathecal administration of the 5-HT_1A agonist 8-OH-DPAT and the NMDA antagonist AP-5 in rats. Brain Res. 1995, 692; 251-258.

3Bjørkum, A.A., Neckelmann, D., Bjorvatn, B. and Ursin R. Lesion of descending serotonergic pathways increases zimeldine-induced waking in rats. Physiology and Behav. 1995, 57; 959-966.

4Bjorvatn, B., A.A. Bjørkum, D, Neckelmann and R. Ursin. Sleep/waking and EEG power spectrum effects of a non-selective 5-HT antagonist and a selective 5-HT reuptake inhibitor given alone and in combination. Sleep, 1995, 451-462.

5Neckelmann, D., Bjørkum A.A., Bjorvatn, B., Ursin R. Sleep and EEG power spectrum effects of the 5-HT_1A antagonist NAN-190 alone and in combination with citalopram. Behav. Brain Res., 1996, 75; 159-168.

6Bjørkum, A.A. and Ursin, R. Sleep/waking effects following intrathecal administration of the 5-HT_1A agonist 8-OH-DPAT alone and in combination with the 5-HT_1A antagonist NAN-190. Brain Res. Bull. 1996, 39; 373-379.

7Bjorvatn, B., D., Neckelmann, A.A. Bjørkum and R. Ursin. Hypothermia and 5-HT syndrome induced by CGS 12066B independently of 5‑HT_1B receptor activation. Behav. Pharmacol. 1996, 7 (5): 462-469.

8Neckelmann D., Bjorvatn B., Bjørkum, A.A., Ursin R. Citalopram: differential sleep/wake and EEG power spectrum effects after single dose and chronic administration. Behav. Brain Res., 1996, 79 (1-2), 183-192.

9Porkka-Heiskanen, T., Strecker, R.E., Thakkar, M., Bjørkum, A.A., Green, R. W. and McCarley R.W. Adenosine; A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness, Science, 1997, 276, (5316), iss. of 23 May, pp. 1265-1268.

10Strecker, R.E., Thakkar, M.M., Porkka-Heiskanen, T., Dauphin, L.J., Bjørkum, A.A. and McCarley R.W. Behavioral state-related changes of extracellular serotonin consentration in the pedunculopontine tegmental nucleus: A microdialysis study in freely moving animals. Sleep Research Online 2(2): 21‑27, 1999.

11Sørensen, E., Grønli, J., Bjorvatn, B., Bjørkum, A.A. and Ursin, R. Sleep and waking following microdialysis perfusion of the selective 5-HT_1A antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat . Brain Res. 2001, 897; 122-130.

12 Chou, T, Bjørkum, A.A., Lu, J., Scammell, T. and Saper, C.B.; Afferents to the ventrolateral preoptic nucleus.

J Neurosci. 2002 Feb 1;22(3):977-990.

13 Lu, J., Bjørkum, A.A., Xu, M., Gaus, S.E., Shiromani, P. and Saper, C.B.; Selective Activation of the Extended Ventrolateral Preoptic Nucleus during Rapid Eye Movement Sleep. , J Neurosci. 2002 Jun 1;22(11): 4568-4576.

14 Bjorvatn, B, Grønli , J, Hamre, F, Sørensen, E, Fiske, E, Bjørkum, A.A., Portas, C.M, and Ursin, R. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Neuroscience. 2002;113(2):323-30.

15 Bjorkum, A. A., Strecker, R.E., Portas C.M., Porkka-Heiskanen, T., Thakkar M. and McCarley R.W. Perfusion of a 5-HT_1A antagonist in the cat dorsal raphe nucleus increases extracellular serotonin and wakefulness, Sleep Research Online, 2003, 5(4): 149-154

16 Kristensen , T., Nybø, R., Bjørkum, A.A., Decision Trees Identifying Changes in Proteome Expression

Induced by Sleep Deprivation, Proceedings of ESM, 2005:262-269 (EUROSITIS-ETI Publication ISBN-90-77381-22-8).

17 Fiske E, Portas CM, Grønli J, Sørensen E, Bjorvatn B, Bjørkum AA, Ursin R. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta Physiol (Oxf). 2008 May;193(1):89-97.

18 Shea JL, Mochizuki T, Sagvaag V, Aspevik T, Bjorkum AA, Datta S. Rapid eye movement (REM) sleep homeostatic regulatory processes in the rat: changes in the sleep-wake stages and electroencephalographic power spectra. Brain Res. 2008 Jun 5;1213:48-56. Epub 2008 Apr 7.

19 Takács E, Nyilas R, Szepesi Z, Baracskay P, Karlsen B, Røsvold T, Bjørkum AA, Czurkó A, Kovács Z, Kékesi AK, Juhász G. Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: a possible role in homeostatic synaptic plasticity.

Neurochem Int. 2010 May-Jun;56(6-7):799-809.

20 Bjørkum AA, Arthurs OJ, Rosendahl K. Changes in gene expression in children after routine 3T magnetic resonance examination Acta Radiol. 2013 Apr 2. [Epub ahead of print]* dette må du sjekke – hva er dette* må være et abstract!

21 Arthurs OJ, Bjørkum AA. Safety in pediatric imaging: an update. Acta Radiol. 2013 Nov;54(9):983-90.

22 Kristensen, T., Jacobsen, V., and Bjørkum A.A. Data Clustering with Visualization of Proteomics Data, 2014, Lambert Academic Publishing, ISBN 978-3-659-31829-0 (book).

23 Arvid Hope, Linda B. Stuhr, Tina Pavlin, Alvhild Alette Bjørkum, Marit Grønning. MRI of the central nervous system in rats following heliox saturation decompression. Undersea and Hyperbaric Medical Journal. 2015 Jan./Feb. 42(1):57-64.

24 Bjørkum AA, Oveland E, Stuhr L, Havnes MB, Berven F, Grønning M, Hope A. Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats. PLoS One. 2017 Oct 4;12(10):e0185765. doi: 10.1371/journal.pone.0185765. eCollection 2017.PMID:28977037 Free Article

25. Bjørkum, A.A., Carrasco Duran, A., Frode, B. et al. Human blood serum proteome changes after 6 hours of sleep deprivation at night. Sleep Science Practice 5, 14 (2021). https://doi.org/10.1186/s41606-021-00066-2

26. N. Musthafa, H.-S.; Walker, J.; Rahman, T.; Bjørkum, A.; Mustafa, K.; Velauthapillai, D. In-Silico Prediction of Mechanical Behaviour of Uniform Gyroid Scaffolds Affected by Its Design Parameters for Bone Tissue Engineering Applications. Computation 2023, 11, 181. https://doi.org/10.3390/computation11090181

27. Bjørkum AA, Griebel L, Birkeland E. Human serum proteomics reveals a molecular signature after one night of sleep deprivation. Sleep Adv. 2024 Jun 19;5(1):zpae042. doi: 10.1093/sleepadvances/zpae042. PMID: 39131770; PMCID: PMC11310596.

B. Andre vitenskaplege publikasjonar med originalt innhald - manuskript (4 in preparation)

1. Bjorkum A.A., Kluge B., Rosendahl, K.. Short term sleep deprivation reduces Heat Shock Protein 70 in human blood serum (manuscript).

2. Bjorkum A.A., Kluge, B., Rosendahl, K.. Short term sleep deprivation reduces SIgA in human saliva (manuscript).

3. Bjorkum AA., Kluge B., Myhre, C., Kjaerstad S, Kristensen, T., Nybo, R., Berven F., Fosse* K., Rosendahl, K.

Specific Proteome Expression Changes in Human Blood Serum after MR-procedure in children (manuscript)

ELLER

3. Bjorkum AA., Kluge B., Myhre, C., Kjaerstad S, Kristensen, T, Holdhus R, Breilid H., Steen V.M.*, inkl. Jonassen, Stavrum og *, Fosse* K., Rosendahl, K.

Specific Genome Expression Changes in Human Blood Serum after MR-procedure in children (manuscript)

4. Bjorkum A.A., Kluge, B., Rosendahl, K.. Specific Proteome Expression Changes in Human Saliva after Short Term Sleep Deprivation

C. Oversiktsartiklar, reviews, bokkapittel, synopsis m.v. med referee-tjeneste (4)

1Ursin, R., Bjorvatn, B., Sommerfelt, L., Neckelmann, D. and Bjørkum, A. A. Studies on sleep-waking effects of serotonin reuptake inhibitors and receptor subtype involvement. Journal of Sleep Research, 1992, 1, 157-162.

2McCarley RW, Strecker, RE, Porkka-Heiskanen, T, Thakkar, M, Bjørkum, AA, Portas, CM, Rainnie, DG and Green, RW. Modulation of cholinergic neurons by serotonin and adenosine in the control of REM and Non-REM sleep. In Hayaishi O and Inoué S, eds. Sleep and Sleep Disorders:From Molecule to Behavior. Tokyo: Academic Press/Harcourt Brace Japan, 1997, pp 63‑79.

3 Bjørkum, A.A. , Pallesen, S. Holsten, F, Bjorvatn, B. Skiftarbeid og ulykker – relevans for offshoreindustrien, Tidsskr Nor Lægeforen, 2004; 124(21):2773-5, review.

4 Pallesen, S. Holsten, F, Bjørkum,A.A. , Bjorvatn, B. Søvnvansker ved nattarbeid, et problem for offshoreindustrien? Tidsskr Nor Lægeforen , 2004; 124(21):2770-2, review.

E. Abstract av foredrag, seminar, m.v. som inneheld originalmateriale, og som ikkje er offentlegjort på annan måte. (34)

1 A.A. Bjorkum, T.T. Kanhema. CHANGE IN THE GENOME AND THE PROTEOME AFTER SLEEP DEPRIVATION. Program No. 965.7. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online.

2 A.A. Bjorkum, K. Rosendahl, S.K. Alvsvaag, E. Stange, H. Åarseth, Å.M. Lien, M.A. Hashmi, T. Kanhema, A.Bjørnstad, B. Kluge, and F.L. Daae. Proteome expression after sleep deprivation. An international meeting in honor of Michel Jouvet: “The paradox of sleep: an unfinished story”, Lyon, 2003, sent abstract, not attended.

3 A.A. Bjorkum, K. Rosendahl , S.K. Alvsvaag, E. Stange, H. Åarseth, Å.M. Lien, M.A. Hashmi, T. Kanhema, F.L. Daae, B. Kluge, and A. Bjørnstad. Sleep deprivation - consequences for proteome expression. Accepted abstract to the 17^th Congress of the European Sleep Research Society, 2004, J. Sleep. Res. 2004, 13,s1;76, Prague

4 A.A. Bjorkum, K. Rosendahl, H.B. Ingebrigtsen, H. Kolstad, I.M. Myhr, S.K. Alvsvaag, E. Stange, T. Kanhema, B. Kluge, and A. Bjørnstad. Sleep deprivation changes proteome expression. APSS 19^th Annual Meeting. A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society, Associated Professional Sleep Society (APSS) Denver, Colorado, USA, June 18-23, 2005, Sleep, 28: A153-A153, 2005

5 AA Bjørkum, C Helgesen, O Ging, P Shiel, B Kluge, C Myhre, S Kjaerstad and K Rosendahl, Cellular response to MR-procedure, Benzonsymposium nr. 52, Cellular responses to DNA damage, Copenhagen 21-25,2005, accepted*.

6. A.A. Bjorkum, K. Rosendahl, I. Holm, M. Kirkevoll, AC Kroksveen, EK Sæterdal, T. Kristensen, R Nybø,T. Kanhema, B. Kluge, and A. Bjørnstad Proteome Expression Changes in Human Blood Serum after Sleep Deprivation by a Decision Tree Classification Method, New Delhi, India, Interim Congress of World Federation of Sleep Research and Sleep Medicine Societies (WFSRSMS), 22-26 September, 2005, accepted*, meeting not attended.

7. Bjorkum, A.A., Rosendahl, K., Aarhus Braseth, T., Nygard,I., Gurvin, I., Kristensen, T., Nybo, R. Differential Expression Proteomics after Sleep Deprivation, European Sleep Research Society, 18^th Congress of the European Sleep Research Society, September 12-16, 2006. , J. Sleep. Res. 2006, 16, s239; P501. Insbruck

8. A.A. Bjorkum, I. Nygaard1, T. Aarhus Braseth1, I. Gurvin1, T. Kristensen, R Nybo, K. Kluge, B. Rosendahl. Differentially Expressed Proteins after Sleep Deprivation, accepted, Nordic Sleep Meeting, Bergen, 2007

9. A.A. Bjorkum, B. Kluge, T. Aarhus Braseth, I. Gurvin, T. Kristensen, R Nybo, K. Rosendahl, I. Nygaard. Changed Protein Profile after Sleep Restriction, World Sleep 2007, Cairns, Australia, Sleep and Biological Rhythms 2007; 5: A91, PO310

10. A.A. Bjorkum, I. B. Kluge, I Nygaard, T. Aarhus Braseth, I. Gurvin, T. Kristensen, R Nybo, K. Rosendahl. Differentially expressed proteins after sleep deprivation including serum Hsp-70 and saliva IgA. Neuroscience, San Diego, USA, 2007, 735.3.

11. S. SAHA¹, V. SAGVAAG², T. ASPEVIK², R. R. MACLEAN³, A. A. BJØRKUM², S. DATTA³, Homeostatic regulation of rapid eye movement (REM) sleep involves increased delta- and decreased theta-frequency wave activities in the cortical electroencephalogram, Neuroscience, San Diego, USA, 2007, 632.4.

12. Bjørkum A, Kluge B, Kjærstad S, Rosendahl K, Genomic change after routine 3T MRI in children, A pilot study. O47, Pediatr Radiol (2008) 38 (Suppl 3):S619–S624 (Europ. Radiol møte oral pres – best score Edinburg 2008.)

13 A.A. Bjorkum*1, I. Nygaard1, T. Aarhus Braseth1, I. Gurvin1, T. Kristensen2,, R Nybo2,, K. Rosendahl 3, B. Kluge 4., Human Serum Protein Profile after Sleep Restriction., Journal of Sleep Research, Volume 17 Issue s1, S08, Pages 1 - 282 (December 2008), Special Issue: Abstracts of the 19th Congress of the European Sleep Research Society, 9-13 September 2008, Glasgow, UK

14. Bjørkum AA, Kluge B, Myhre C, Kjaerstad S, Rosendahl K. Proteomic and Genomic Changes after Routine Magnetic Resonance Imaging (MRI) in Children. A Pilot Study. Bergen University College, Great Ormond Street Hospital and Institute for Surgical Sciences, University of Bergen, Poster, Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

15. A.A. Bjørkum*1, T. Aarhus Braseth1, I. Nygaard1, I. Gurvin1, T. Kristensen2, R. Nybo2, B. Kluge3, K. Rosendahl4. Human Serum Protein Profile and Protein Identification after Sleep Restriction, talk, Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

16. Terje Kristensen, Vemund Jakobsen and Alvhild A. Bjørkum. Computational Proteomics – A Pattern Solutions Approach. Poster, Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

17. TERJE KRISTENSEN, VEMUND JAKOBSEN, ALVHILD ALETTE BJØRKUM, Different Visualization

Schemes of Protein Data Clustering. FOURTEENTH INTERNATIONAL CONFERENCE

ON COGNITIVE AND NEURAL SYSTEMS. Boston 19-22 May, 2010, submitted.

18. A.A. Bjørkum*1,T. Gurvin1, T. Aarhus Braseth1, I. Nygaard1, I.,T. Kristensen1, R., B. Kluge2, K. Rosendahl3

Protein Identification of Changed Protein Levels by Proteomics after Sleep Restriction

20th Congress of the European Sleep Research Society, Lisboa 2010, accepted as oral presentation.

19. A.A. Bjørkum*1,T. Gurvin1, T. Aarhus Braseth1, I. Nygaard1and K. Rosendahl2. Protein Identification and Changed Levels by Proteomics after Sleep Deprivation, , SLEEP 2010 24th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS), June 5- 9, 2010, San Antonio, Texas, USA, submitted

20. Kristensen, T., Jakobsen,V., Monsen, R.A., Bjørkum, A.A. Kluge, B. Data Protein Clustering –some Adaptive Algorithms. Poster on RECOMB Workshop on Computational Cancer Biology 2010, June 24-25, Oslo, Norway.

21. Kristensen,T., Bjørkum, A.A. Simulation of Biological Networks - a Multiagent (MAS) Framework. Poster on Conference for New Concept in NeuroScience. 26-28 May 2010, Bergen, Norway.

22. A. Bjørkum*1,I. Gurvin1, T. Aarhus Braseth1, I. Nygaard 1, K. Rosendahl2. Protein-ID and Changed Protein levels by Proteomics in Human Blood Serum after Sleep deprivation. SLEEP 2011 25th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS), June 2011, Minneapolis, USA, submitted Dec. 2010, Accepted poster presentation. VOLUME 34, 0119, p A45, 2011 Abstract Supplement

23. A.A. Bjørkum*1,I. Gurvin1, I. Nygaard1, T. Aarhus Braseth1,T. Kristensen2, R., B. Kluge3, K. Rosendahl4. Protein Identification and Changed Protein Levels after Sleep Deprivation. 20^th International Symposium on Shiftwork and Working Time – Biological mechanisms, recovery and risk management in the 24h society, June 28-July 1, 2011, Stockholm, Sweden. Accepted oral presentation. Shiftwork international newsletter, SIN, p. 228, Volume 25, 2011. ISBN 0265-5357.

24. Arvid Hope, Marianne B Havnes, Alvhild Bjørkum, Linda B Stuhr, Marit Grønning. Protein Expression Profiles in Brain and Protein S100b in Serum following Heliox Saturation Decompression in Rats. The 37th Annual Scientific Meeting of the European Underwater and Baromedical Society (EUBS), 24-27 August, 2011, Gdansk, Poland.

25. A.A. Bjørkum*1,I. Nygaard1, T. Aarhus Braseth1,T. Kristensen2, R., B. Kluge3, K. Rosendahl4. Protein Identification and Changed Protein levels after Sleep deprivation. SLEEP 2012 26th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS), June 9-13, 2012, Boston, USA, accepted, poster presentation.

26. Alvhild A. Bjørkum, Owen Arthurs, Karen Rosendahl Pediatric MRI-safety revisited, 50^th Annual Meeting and 36^th post Graduate Course of the European Society of Paediatric Radiology, Budapest, Hungary, June 3-7 2013, Pediatric Radiology, Pediatr Radiol (2013) 43 (Suppl 3):S459–S656

27. Bjørkum Alvhild Alette (1), Sinha Roy Dola (1), Duran Ana Carrasco (1), Kristensen Terje (2), R. Kluge Beate (3), Rosendahl Karen (4) Proteomic Changes in Human Blood Serum after Sleep Deprivation. Gordon Research Conferences, Sleep regulation and Function, Galveston Texas, March 16-21, 2014. Invited talk and poster.

28. Carrasco Duran A., Sinha Roy D., Bjørkum A.A. Changes in Human Blood Serum Proteome after 6 Hours of Sleep Deprivation at Night. Sleep Training Workshop at UCLA Lake Arrowhead Conference Center, September 9-14, 2014.

29. Bjørkum Alvhild Alette (1), Sinha Roy Dola (1), Duran Ana Carrasco (1), Kristensen Terje (2), R. Kluge Beate (3), Rosendahl Karen (4). Stress på cellene I kroppen etter nattarbeid påvirker proteinene I blodet vårt - Endrede proteiner I humant blodserum etter søvnmangel (SD) - en proteomisk studie - potensiell biomarkørprofil - cellestress ved SD? FoU-dag 11.11.2015, Høgskolen i Bergen.

30. Alvhild Bjørkum, Linda B Stuhr, Marianne B Havnes, Eystein Oveland, Frode Berven, Marit Grønning, Arvid Hope. Protein Expression Profiles in Brain and Protein S100b in Serum following Heliox Saturation Decompression in Rats. FoU-dag 11.11.2015, Høgskolen i Bergen.

31. Bjørkum AA, Kluge B, Myhre C, Kjaerstad S, Rosendahl K. Changes in gene expression in children after routine 3T magnetic resonance examination. FoU-dag 11.11.2015, Høgskolen i Bergen.

32. Beate Kluge1, Mihaela R. Cimpan2, Kamal B. E. Mustafa2, Karen Rosendahl3, Alvhild A. Bjørkum4. Effekt av cellestress som liten temperaturøkning på cellekultur - celletype Saos-2 – ved impedansmåling. FoU-dag 11.11.2015, Høgskolen i Bergen.

33. Kristian Hestetun, Marcus Karlsen, Alvhild Alette Bjørkum, Kari Rostad and Terje Kristensen. Can a computer learn to recognize DNA-sequences? FoU-dag 11.11.2015, Høgskolen i Bergen.

33. Bjørkum A.A, Carrasco Duran A., Sinha Roy D. Human Blood Serum Proteome Changes after Six Hours of Sleep Deprivation. Winter Meeting of the Norwegian Physiological Society, Geilo, January 28-31, 2016.

33 Bjørkum et al. 2017? Norwegian Sleep Meeting?

34. A.A. Bjorkum*1, I Frich Meling1, B. Kluge2, and K. Rosendahl3. Changes in Human Salivary Proteome after Six Hours of Sleep Deprivation at Night, Neuroscience meeting, November 3-7, 2018, San Diego.

35. Alvhild Alette Bjørkum*1, Jakob Tangen Olsen1, Hannah Hvesser1, Nasra Omar1, Frode Berven2,3 and Even Birkeland2,3. Human serum protein changes after 6 h of sleep deprivation investigated with newer proteomic methods. 16th World Sleep congress in Rome, Italy, March 11–16, 2022.

35, A.A. Bjørkum, J.T. Olsen, H. Hvesser, N. Omar, F. Berven, E. Birkeland,

Human serum protein changes after 6 h of sleep deprivation investigated with newer proteomic methods,

Sleep Medicine, Volume 100, Supplement 1, 2022, Page S18, ISSN 1389-9457,

https://doi.org/10.1016/j.sleep.2022.05.064. (https://www.sciencedirect.com/science/article/pii/S1389945722002489)

36. Bjørkum A.A, Griebel, L. and Birkeland, E.. Human serumproteomics reveal molecular signature of sleep deprivation at night. ESleep Europe 2023, Virtual Congress, October 4-6, 2023

F. Abstract med innhold som ellers er offentleggjort gjennom dei vitskaplege publikasjonar. (38)

1 Bjørkum, A.A. and Berge, O.-G. The relative importance of ascending and descending serotonergic pathways in PCA induced analgesia. Acta Physiol. Scand. 1986, 128; 25a.

2 Bjørkum, A.A. and Ursin, R. The relative contribution of the descending serotonergic pathways in zimeldine induced sleep and wakefulness. Journal of Sleep Research. 1992, 1, 1; 25.

3 Bjørkum, A.A. and Ursin, R. Stimulation of 5-HT_1A receptors and blocking of NMDA receptors in the rat spinal cord cause changes in sleep and waking. Sleep Research. 1993, 22; 489.

4 Bjørkum, A.A., B. Bjorvatn and R. Ursin. Increase of total slow wave sleep after 5-HT_1A agonist and increase of REM sleep after NMDA antagonist, administered in the rat spinal cord. Acta Physiol. Scand. 1995, 153: 43A

5 Bjørkum, A.A. and Ursin, R. Sleep and waking following the 5-HT_1A agonist 8-OH-DPAT and the 5-HT_1A antagonist NAN-190 administered intrathecally in rats. Sleep Research. 1995, 24A; 110.

6 Bjorvatn, B., A.A. Bjørkum and R. Ursin. Methiothepin blocks waking effect of the 5-HT reuptake inhibitor zimeldine in rats. Acta Physiol. Scand. 1995, 153: 44A

7 Bjørkum, A.A., Strecker, R.E., Porkka-Heiskanen, T. and McCarley R.W. Perfusion of a 5-HT_1A

antagonist in the dorsal raphe nucleus (DRN) increases serotonin (5-HT) release in DRN and decreases REM sleep. Soc. Neurosci. 1996, 22:148

8 Porkka-Heiskanen, T., Strecker, R.E., Bjørkum, A.A. and McCarley R.W. Changes in extracellular basal forbrain adenosine levels during spontaneus sleep-waking and prolonged wakefulness. Soc. Neurosci. 1996; 22:149.

9 Porkka-Heiskanen, T., Strecker, R.E., Bjørkum, A.A. Portas, C.M. and McCarley R.W. Microdialysis measurement of basal forebrain adenosine levels during sleep-waking. J. Sleep. Res. 1996, 5,1;183.

10 Strecker, R.E., Porkka-Heiskanen, T., Thakkar, M., Bjørkum, A.A. and McCarley R.W. Microdialysis perfusion of an adenosine uptake inhibitor in the basal forbrain increases sleep. Soc. Neurosci. 1996; 22:26.

11Strecker, R.E., Porkka-Heiskanen, T., Thakkar, M., Bjørkum, A.A. and McCarley R.W. 1. Changes in extracellularbasal forebrain adenosine levels during spontaneous sleep-waking and prolonged wakefulness, and 2. Microdialysis perfusion of an adenosine uptake inhibitor in the basal forebrain increases sleep. Boston Area Neuroscience Group Meeting (BANG-meeting) 1996.

12 Bjørkum, A.A., B. Bjorvatn, Neckelman, D. and R. Ursin. Modulatory role of the descending serotonergic system in sleep and waking. Nordic Sleep Congress, Scandinavian Societies for Sleep Research, Bergen, Norway, 1997.

13 Bjørkum, A.A., Porkka-Heiskanen, T., Portas, C.M., Strecker, R.E, Stenberg, D. and McCarley R.W Serotonin and GABA inhibit dorsal raphe nucleus and increase REM sleep as revealed by microdialysis. Nordic Sleep Congress, Scandinavian Societies for Sleep Research, Bergen, Norway, 1997

14 Bjørkum, A.A., Strecker, R.E., Porkka-Heiskanen, T., Stenberg, D. and McCarley R.W. GABA modulates the dorsal raphe and alters the pattern of sleep-waking. Soc. Neurosci. 1997; 23:419.7

15 Bjørkum, A.A., Strecker, R.E., Porkka-Heiskanen, T., Stenberg, D. and McCarley R.W. Sleep-waking pattern is altered by GABA modulation of the dorsal raphe nucleus in cats. Sleep Research Society, Summer Sleep Workshop, Abs. 1997, accepted and selected for oral presentation.

16 Porkka-Heiskanen, T., Strecker, R.E., Stenberg, D., Bjørkum, A.A. and McCarley R.W. GABA and adenosine inhibit the dorsal raphe nucleus and increase REM sleep as studied by microdialysis, Sleep Research 1997; 26: 35

17 Strecker, R.E., Porkka-Heiskanen, T., Bjørkum, A.A. and McCarley R.W. Adenosine actions on the dorsal raphe nucleus: altered sleep-waking pattern. Soc. Neurosci. 1997, 23: 419.8

18 Strecker, R.E., Porkka-Heiskanen, T., Bjørkum, A.A.,Thakkar, M. and McCarley R.W. Is adenosine a physiological sleep factor? Evidence from microdialysis studies, Sleep Research 1997; 26: 46

19 Thakkar, M., Bjørkum, A.A., Strecker, R.E., Porkka-Heiskanen, T. and McCarley R.W. Perfusion of 5-HT1Aagonists in the laterodorsal tegmental nucleus (LDT) inhibits REM-on neurons but has no effect on waking and REM-onneurons as revealed by combined microdialysis and unit recording. BANG-meeting, 28 april, 1997.

20 Bjørkum, A.A., Portas C.M., Bjorvatn, B., Sørensen, E.,Grønli, J. and Ursin, R., Dialysis Perfusion of a 5-HT_1A Receptor Antagonist in Dorsal Raphe Nucleus Increases 5-HT Levels in Sleep and Waking. Soc. Neurosci. 1998, 24:12.5

21 Bjørkum, A.A., Portas C.M., Bjorvatn, B., Sørensen, E.,Grønli, J. and Ursin, R., Microdialysis Perfusion of a 5-HT_1A Receptor Antagonist in Dorsal Raphe Nucleus Change 5-HT Levels in Sleep and Waking. J. Sleep. Res. 1998, 7,2;51.

22 Bjørkum, A.A., Portas C.M., Bjorvatn, B., Sørensen, E.,Grønli, J. and Ursin, R., Perfusion by microdialysis of a 5-HT_1A Receptor Antagonist in Dorsal Raphe Nucleus Increases 5-HT Levels in Sleep and Waking, Serotonin 50th anniversary, Princeton University 1998

23 Bjørkum, A.A., Portas C.M., Bjorvatn, B., Sørensen, E.,Grønli, J. and Ursin, R., A 5-HT_1A Receptor Antagonist Administered by Microdialysis in Dorsal Raphe Nucleus Increases 5-HT Levels in Sleep and Waking in Rats

Sleep Research Society, Summer Sleep Workshop, 1998

24 Silveira, D.C., Bjørkum, A.A., Schomer, D.L., Schachter, S.C. Fos Expression in Raphe Nuclei Following Seizures Induced by Kainic Acid in Rats. Epilepsia, Vol. 39. Suppl. 6, 1998

25 Bjørkum, A.A. and de Lacalle, S. Long Term Sleep-Wake EEG/EMG Recordings in Rats after Unilateral Intraparenchymal Infusion of Spesific Cholinergic Toxin 192 IgG-Saporin into the Diagonal Band of Broca. Sleep, Vol. 22, Suppl. p. S232, 1999

26 Bjørkum, A.A., Ha, Q.H. and Saper C.B. Afferents to and efferents from the raphe nuclei to the ventrolateral preoptic nucleus, Soc. Neurosci. 1999, 25:250.2

27 de Lacalle S. and Bjørkum, A.A. Long term effects of cholinergic lesion of the nucleus of the Diagonal Band of Broca: Sleep-Wake EEG/EMG recordings in rats, Soc. Neurosci. 1999, 25:857.10

28 Sørensen, E., Bjorvatn, B., Bjørkum, A.A. and Ursin, R. Sleep and Waking Following Perfusion of a Selective 5-HT_1A antagonist in the dorsal raphe nucleus in rats. Sleep, Vol. 22, Suppl. 1, p.31, 1999

29 Bjørkum, A.A., Ha, Q.H. and Saper, C.B. Connections between the raphe nucleus and the ventrolateral preoptic nucleus. World Federation of Sleep Research Societies, Third International Congress.Sleep Research Online, 1999, Vol.2 (Supplement 1),10

30 Bjørkum, A.A., McCarley, R.W. 5-HT Agonist and Antagonists Administered Locally in Brainstem Areas : Consensus on Localization and Effect on Sleep and Waking. World Federation of Sleep Research Societies, Third International Congress. Suggested and co-Chaired Symposium. Sleep Research Online, 1999, Vol.2 (Supplement 1),?*

31 Bjørkum, A.A., Portas C.M., Bjorvatn, B. and Ursin, R. Microdialysis perfusion of 5-HT_1A receptor ago- and antagonists in dorsal raphe nucleus - changes in 5-HT levels and behavioral state. World Federation of Sleep Research Societies, Third International Congress. Suggested and co-Chaired Symposium. Sleep Research Online, 1999, Vol.2 (Supplement 1), 647.

32 Bjørkum, A.A., Saper, C.B. and McCarley, RW. What to prefere and why: Microdialysis versus microinjections in in vivo sleep-wake studies. World Federation of Sleep Research Societies, Third International Congress. Suggested and co-Chaired Workshop. Sleep Research Online, 1999, Vol.2 (Supplement 1), 743.

33 Bjørkum, A.A., Saper, C.B. What does c-fos tell us about sleep and wake active areas in the brain - supporting old and creating new hypotheses? World Federation of Sleep Research Societies, Third International Congress. Suggested Caired Focus Group. Sleep Research Online, 1999, Vol.2 (Supplement 1),11.

34 Ursin, R, Grønli , J, Sørensen, E, Bjørkum, A.A., and Bjorvatn, B. A single dose of the adenosine A₁ antagonist 8-cyclopentyl-theofylline (CPT) increases hippocampal serotonin during waking in rats as measured with microdialysis. Submitted and accepted abstract to the 15^th Congress of the European Sleep Research Society, September 12-16, 2000.

35 Bjorvatn, B, Grønli , J, Hamre, F, Sørensen, E, Fiske, E, Bjørkum, A.A., Portas, C.M, and Ursin, R. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. World Federation of Sleep Research Societies, 4rd International Meeting 2001, accepted.

36 Bjørkum, A.A. Role of serotonin in REM sleep mechanisms - preclinical evidence. World Federation of Sleep Research Societies, 4rd International Meeting 2001, accepted.

37 Fiske, E., Grønli , J, Hamre, F, Bjørkum, A.A., Portas, C.M, and Ursin, R. Investigation of the effect of bicuculline perfused in DRN on sleep, waking and 5-HT levels in the DRN and FC. Submitted abstract to the 16^th Congress of the European Sleep Research Society, June 3-7, 2002.

38 Fiske E, Gronli J, Hamre F, Bjorkum AA, Portas CM, Ursin R Effect of bicuculline perfused in DRN on 5-HT levels in the DRN and FC. Sleep 26: A17-A17 May 15 2003.

G. Annan publikasjonstype

Bjørkum, A.A. Lesjon av ascenderande og descenderande serotonerge baner hjå rotte svekkjer den smertehemmande effekten av p-kloroamfetamin. Hovudfagsoppgåve/Master thesis, Universitetet i Bergen 1987.

Other publications 1

Bjørkum supervised main Projects at Bergen University College (BUC/HIB, later WNUAS/HVL), Biomedical Laboratory Sciences Program and Bjørkum’s collaborative R&D-institutions as Harvard University and other collaborative institutions. (Students ca. ca 100, 64 abroad, total 52 bachelor projects), later Master, later PhD

1. Bratland, E., Kristoffersen G., Sørhus E. Nevronal aktivitet i søvn-og våkentaktivt relaterte nevroner. Kan immunohistokjemisk merking av proteinet c-Fos gi oss informasjon om søvn og våkenaktive nerveceller i hjernen? BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2002.

2. Agledal, L. Determining cyclic AMP in rat cortical neuronal cultures using high performance liquid chromatography and enzyme immunoassay. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2003.

3. Alvsvåg, SK., Stange, E. Proteinekspresjon etter søvndeprivasjon. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Rogalansforskning/International Research Institute Stavanger (IRIS), Stavanger, NO, 2003.

4. Skartland, LK, Sund, N. Immunohistochemistry as a Method to detect Cholinergic Neurons in Basal Forebrain. The Effect of Sleep Deprivation on the Expression of Hsp72(i). BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and VA Boston Heathcare System West Roxbury, Boston, USA, 2003.

5. Aarset, H, Lien ÅM, Hashmi AM. Genekspresjon av hydrogenperoksidase og Hsp 70 ved søvndeprivasjon. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO, 2003.

6. Ingebrigtsen,HB, Kolstad, H, Myhr, IM. Reduksjon i heat shock protein 70 i humant serum etter søvndeprivasjon målt med en ELISA metode. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO, 2004.

7. Lomheim IJ, Rasmussen, E, Myhre, C, Lied Belt, B. Preanalytiske forhold ved proteomiske analyser. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO, 2004. -18

8. Brattaas, M. Changes in small intracellular proteins and peptides in physiologically and neurochemically controlled epileptic cellular stress in rat cortex. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2004.

9. Holm, I, Kirkevoll, M, Kroksveen, AC, Sætersdal, EK., BUC/HIB, Proteomiske analyser ved cellulært stress. Biomedical Laboratory Sciences Program, Bergen, NO, 2005.

10. Sleire, L, Karlsen I.F. The Role of GABAergic (non-cholinergic) Neurons In Basal Forebrain Involved in Activation of the Cerebral Cortex, BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard Medical School, Harvard University, Boston, USA, 2005.

11. Fimland, A.E., Gustad, A-K., Tangenes Os, I., Olsvik, M. Proteomisk analyse etter MR-undersøking av born. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO, 2006.

12. Øines, E., Ofte ML., Sleep Deprivation-Induced Changes in the Synaptic Proteins in Rat Hippocampus. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard Medical School, Harvard University and VA Boston Heathcare System West Roxbury, Boston, USA, 2006.

13. Karlsen, B., Rosvold, T.C., Induction of MMP9 in Absence Epileptic Rats. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2006.

14. Padøy, T., Haugland, G.,Magnussen, G. Endring av immunglobulin A i humant saliva ved lett søvndeprivasjon målt med ELISA metode. Biomedical Laboratory Sciences Program, Bergen, NO, 2007.

15. Haukeland, M.L., Klungtveit, N, Bru, S., Jensen, H.S., Effekter av hypoksisk stress på laks. BUC/HiB, Biomedical Laboratory Sciences Program and Institute of Marine Research Bergen, NO, 2007.

16. Aspevik, T., Sagvaag, V., Electrophysiological Signs of Rapid Eye Movement Homeostasis. Sleep Research Laboratory, Dept. of Psychiatry, Boston University School of Medicine, Boston University, Boston, USA, 2007.

17. Myrlien, A., Johnsen, M., Comparative Proteomics of Sleep Deprived Anxiety Model Mice. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2007.

18. Myrmel, SL., Varnes, BK., Nilsen-Nygaard, J., Endring av alpha-amylaseaktivitet i humant saliva etter lett søvndeprivasjon. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO, 2008.

19. Kornberg, G., Tveiten, H., How does Sleep Deprivation and Recovery Sleep Affect Proteins that regulate Synaptic Plasticity? BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and SRI International Bioscience Division, San Francisco, USA, 2008.

20. Busk, S.A., Skogland, K., Inflammation and Sleep. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2009.

21.Grebstad Lødøen, L., Dysvik, R. ER proteins from hypothalamus undergo more oxidative damage in aged than in young mice than the proteins in general. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2009.

22.Markussen, C. Sleep deprivation and long-term molecular tuning of brain cells. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Institute of Biology, Proteomics Laboratory, Budapest, Hungary, 2009.

23.Skartveit, L., Hovland, M. Homeostatic regulation of sleep: The role of VLPO. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2009.

24. Kjelstrup, S. And Davidsen Bekken S. Immunohistochemical detection of parvalbumin positive neurons in an animal model of schizophrenia. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and Children's Hospital, Boston, USA, 2010.

25. Sivertsen Åserud K. and Lundegaard Eidahl JM. Effect of sleep loss on endothelial growth factor. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2010.

26. Dybvik M and Rønnestad KT. Oscillatory impairments and structural deficits in the GABAergic-neuron network in an animal model of schizophrenia. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and Children's Hospital, Boston, USA, 2011.

27. Talgø NM and Tolås I. The unfolded protein response after sleep deprivation in pancreas cells change with age. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2011.

28. Sarria SVC and Gjøstein R. Immunoglobulin binding protein (BiP) across aging – a study in Drosophila melanogaster. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2012.

29. Fosen Simonsen A and Torvestad A. Optogenetic targeting of midbrain raphe neurons. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and Children's Hospital, Boston, USA, 2012.

30. Sira C and Sæverås M. A study in immunoglobulin binding protein (BiP) across aging in Drosophila melanogaster. BUC/HIB, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2013.

31. Ormberg CH and Lindborg I. Changes in the neuronal gap junction protein Connexin36 with prolonged waking. BUC/HIB/HiB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and VA Boston Healthcare System West Roxbury, Boston, USA, 2013.

32. Bårholm HM and Kaknita Eap K. The Effect of Thapsigargin and Dantrolene on Sleep and the Unfolded Protein Response in Drosophila melanogaster. BUC/HiB, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2014.

33. Midtbø. Proteomic changes in adult rat brain after Clomipramine treatment in early developmental stage. BUC/HiB, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2014.

34. Brandt M and Hjørnevik S. Histological verification of virus injection in rat brains for manipulating neuronal activity related to schizophrenia. BUC/HiB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and Children's Hospital, Boston, USA, 2015.

35. Mo, K. Engedal and Von Krog, Å. Sanam. Activation of median raphe nucleus by Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) and the Effect on Hippocampal Theta Frequency. BUC/HiB, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and Children's Hospital, Boston, USA, 2016.

36. Haarstad, Karen Juni and Nguyen, Myse. The effect of Pharmacological inhibition of the Unfolded Protein Response on Sleep in Drosophila melanogaster. BUC/HiB, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2016.

37 Guldbrandsøy, J and Rødset S. Changes in human blood serum proteome after 6 hours of sleep deprivation at night. BUC/HiB, Biomedical Laboratory Sciences Program, Bergen, NO, 2016.

38. Kristiansen, A. and Hjaltadottir, J. Can vasoactive intestinal peptide neurons in the suprachiasmatic nucleus influence electrocortical and behavioral arousal, Department of Biomedical Laboratory Sciences and Chemical Engineering,

Faculty of Engineering and Business Administration, Western Norway University of Applied Sciences, Bergen, NO and Department of Neurology, Harvard Medical School, Harvard University and Beth Israel Deaconess Medical Center, Boston, USA, 2017.

39. Ingjerd Frich Meling. Changed protein expression in saliva after 6 hours of sleep deprivation at night

- a proteomic and systems biological study. Department of Biomedical Laboratory Sciences and Chemical Engineering,

Faculty of Engineering and Business Administration, Western Norway University of Applied Sciences, Bergen, NO, 2017.

40 Berland, C. og Skjelde, L. Study of MMP-9 citrullination and activity in systemic autoimmune diseases. Laboratory of Immunobiology, Rega Institute for Medical Research, Leuven, Belgium and Department of Biomedical Laboratory Sciences and Chemical Engineering, Faculty of Engineering and Sciences, Western Norway University of Applied Sciences, Bergen, NO, 2018.

41. Slettebø, R., Utslottøy Mathiesen, K., Clark, J., Bjørkum, A.A. and Fuller, P. Neuronal activity in the Rodent brain following sleep deprivation. Department of Biomedical Laboratory Sciences and Chemical Engineering,

Faculty of Engineering and Science, Western Norway University of Applied Sciences, Bergen, NO and Department of Neurology, Harvard Medical School, Harvard University and Beth Israel Deaconess Medical Center, Boston, USA, 2019

42. Knutsen, T., Lærdal, K. og Bildøy, S. Sammenligning av biometriske mål i en søvndeprivasjonsstudie målt med to ulike målemetoder – Oura-ring og Somnofy. Department of Biomedical Laboratory Sciences and Chemical Engineering, Faculty of Engineering and Sciences, Western Norway University of Applied Sciences, Bergen, NO, 2019.

43. Bergesen, J. I., Nedreberg Nybakk, J. og Sande, S. Proteinmarkører for cellestress ved nattskiftarbeid. Department of Biomedical Laboratory Sciences and Chemical Engineering, Faculty of Engineering and Sciences, Western Norway University of Applied Sciences, Bergen, NO, 2019.

44. Skogøy Innvær, K and Hereid Myklatun, S. Sleep deprivation and its consequences on health – with emphasis on metabolic and immunological functions. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO and Dept. of Psychiatry, Harvard Medical School, Harvard University and VA Boston Healthcare System West Roxbury, Boston, USA, 2020

45. Ekerhaug, Bryn Silje, Løken, Hoddevik Marte and Storesund Idunn. Mechanisms of IL-1 in the Brain Related to Fever and Depression - Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2020.

46. Dregi, Sofie Othilie, Eliassen Stokkenes, Frida and Halse Hanna. The role of C1q and Synaptic Pruning in Alzheimer’s Disease. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2020.

47. Hvesser, Hannah, Tangen Olsen, Jakob og Omar, Nasra. Proteinmarkører i humant serum etter simulert nattskift, undersøkt med nyere proteomiske metoder. Department of Biomedical Laboratory Sciences and Chemical Engineering, Faculty of Engineering and Sciences, Western Norway University of Applied Sciences, Bergen, NO, 2021

48. Holme Kvammen, Elise and Jomaas Ingvild. The function of the Activity-Regulated Cytoskeleton associated protein (Arc) based on literature. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2021. -109

49. Skårhaug Jacobsen, Anita, Dyrøy Lotsberg, Ingeborg og Pettersen, Michelle Louise. Endrede nivåer av distinkte proteiner i humant blodserum etter 6 timer søvndeprivasjon på natt. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO, 2022

50. Leirvoll, Astrid L., Moe, Jenny og Øye, Frøy H. Effekten av 6 timers søvnmangel på natt på reaksjonstid og arbeidshukommelsestester. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO, 2022

51. Birkeland Marte. Funksjonalitetstest av nettbasert treningssenter for optimal søvn, døgnrytme, læring og hukommelse. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO, 2023

52. Fladhus E.K. and Sørjoten A. Transcriptional Burst Kinetics in Neurons. Biomedical Laboratory Sciences Program, Western Norway University of Applied Sciences, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2023.

Other publications 2 (4)

1. Daae FL, Bjørkum AA. Innføring i DNA teknologi for bioingeniører, våren 2003. Ekstraksjon av DNA, Elektroforese, PCR, Restriksjon, Sekvensering. HiB-publikasjon 2003

2. Daae FL, Bjørkum AA. Innføring i DNA teknologi for bioingeniører, Ekstraksjon av DNA, Elektroforese, PCR, Restriksjon, Sekvensering. våren 2004, ISBN 82-513-0026-6

3. Daae FL, Bjørkum AA. Innføring i DNA teknologi for bioingeniører, Ekstraksjon av DNA, Elektroforese, PCR, Restriksjon, Sekvensering. våren 2005, ISBN 82-7709-080-3

4. Salinas Remiro I. and Bjørkum AA Histology, laboratory journal, 2007

Other publications 3 (1)

1. Pandi-Perumal SR, Kumar VM, Pandian NG, de Jong JT, Andiappan S, Corlateanu A, Mahalaksmi AM, Chidambaram SB, Kumar RR, Ramasubramanian C, Sivasubramaniam S, Bjørkum AA, Cutajar J, Berk M, Trakht I, Vrdoljak A, Meira E Cruz M, Eyre HA, Grønli J, Cardinali DP, Maercker A, van de Put WACM, Guzder J, Bjorvatn B, Tol WA, Acuña-Castroviejo D, Meudec M, Morin CM, Partinen M, Barbui C, Jordans MJD, Braakman MH, Knaevelsrud C, Pallesen S, Sijbrandij M, Golombek DA, Espie CA, Cuijpers P, Agudelo HAM, van der Velden K, van der Kolk BA, Hobfoll SE, Devillé WLJM, Gradisar M, Riemann D, Axelsson J, Benítez-King G, Macy RD, Poberezhets V, Hoole SRH, Murthy RS, Hegemann T, Heinz A, Salvage J, McFarlane AC, Keukens R, de Silva H, Oestereich C, Wilhelm J, von Cranach M, Hoffmann K, Klosinski M, Bhugra D, Seeman MV. Scientists Against War: A Plea to World Leaders for Better Governance. Sleep Vigil. 2022 Mar 18:1-6. doi: 10.1007/s41782-022-00198-0. Epub ahead of print. PMID: 35317215; PMCID: PMC8930284.