Curriculum Vitae

 

Name:                                       Alvhild Alette Bjørkum

Date of birth:                            February 10, 1962

Birthplace:                                Årdal, Norway

Address                                    Fløenbakken 39E, N-5009 Bergen, Norway

Telephone:                                Home: 47 55 201940 or 55 917611, Work, office 47 55 58 7627, fax 4755 58 7790

E-mail:                                     Alvhild.Bjorkum@hib.no

 

Education

1996                         Ph.D. (Dr. Sci.) Neurophysiology, University of Bergen, Norway

1987                         M.Sci. (Cand. scient.) Human and zoological physiology, Department of Physiology, Medical Faculty, University of Bergen, Norway

1985                         B.Sci. (Cand. mag.), chemistry and biology, University of Bergen, Norway

 

Experience

2002-                        Associate Professor, Faculty of Engineering, Biomedical Laboratory Sciences Program, Bergen University College, Norway

2001                         Research coordinator, Department of Health, Bergen University Research Foundation (UNIFOB)
1999-                        Postdoctoral stipend from The Norwegian Research Council, Dept. of. Medicine

1998-                        Visiting Associate Professor from March 1998. Invited by Professor and Chairman Clifford B. Saper

Department of Neurology, Harvard Medical School, Harvard University, Massachusetts, USA

1997-                        Associate Professor from June 1997

Department of Physiology, Medical Faculty, University of Bergen

1995-1997                  Research Fellow, Fulbright Foundation, Department of Psychiatry Harvard Medical School,

Invited by Director and Chairman Professor Robert W. McCarley

1990-1994:                 Research fellow, Department of Physiology, Medical Faculty, University of Bergen

1989-1990:                 Senior Executive Officer at the Norwegian Research Council for Science and Humanities,                        

                                Council for Medical Research (NRC, CMR), Oslo, Norway

1988-1989:                 Scientist at The Norwegian Medicine Control Authority, Oslo, Norway

 

Teaching Experience

2002-                        Teaching 15 credits (ECTS) spring, 30 credits autumn, Faculty of Engineering, Biomedical Laboratory Sciences Program, Bergen University College, Norway

1999-2001                  25 % teaching and other mandate work, Department of Physiology, Medical Faculty, University of Bergen

1997-                        50 % teaching and other mandate work, Department of Physiology, Medical Faculty,                                                                                                                                              University of Bergen

1990-1994                           25% teaching and other mandate work, Department of Physiology, Medical Faculty,

                                University of Bergen

1991-1993 Physiology, lab.course and lecturing, 5 credit course for science students, master level, 3 days each year

1990-1993 Physiology, lab.course and lecturing, medical and dentistry students, 3 weeks each year

1991-1992 Part time lecturer (50%) University Hospital Nursing School; in physiology and anatomy. 60 hours lecturing per semester pr. class, total 120 hours

                                 (two classes)

 

Administrative Positions/Organizing work

2008                         Norwegian Association of Research Workers – NARW, nominated and elected as deputy for Section Council, Faculty of Engineering, Bergen University College and vice-deputy for Bergen University College

2007-                        Board of Bergen University College, elected deputy/substitute representing the research- and lecturing-personnel

2007-                        Section Council, Faculty of Engineering, Bergen University College, elected member representing the research- and lecturing-personnel

2004                        IS(ICT)-system board, member, Faculty of Engineering, Bergen University College (BUC)

2003-                        Norwegian Association of Research Workers – NARW, nominated and elected board member and vice-chairman from 2006, Faculty of Engineering, BUC

2001                         Research coordinator, Department of Health, Bergen University Research Foundation (UNIFOB)

2001                         Member of the Board of the Faculty of Medicine, University of Bergen

1999                         Inititiative, organizing and Chairman of one Symposium, one Focus Group and one Workshop on World Federation of Sleep Research Societies (WFSRS) Third International Congress, Dresden, Germany

1997                         Scientific and organizing Head of the international meeting; In vivo Microdialysis in The Central Nervous System in Animals and Humans, December 6-7, 1997 at the Department of Physiology, University of Bergen

1993                         Member of The Council of the Faculty of Medicine, University of Bergen

1993                         Member of the Board of the Faculty of Medicine, University of Bergen

1991-1993 Member of The Council of the Department of Physiology, University of Bergen

1991-1993 Member of the Board of the Department of Physiology, University of Bergen

1991-1992 Member of the Council at the University of Bergen

1992                         Head for the Sleep Research Laboratory in the absence of Prof. Ursin, 6 months Research leave.

 

Awards and Honors: 

2009                         Lecturing-Milieu Award for student-active Research at the Biomedical Laboratory Science Program at Bergen University College

1998                         3-year grant Research Council of Norway, Division of Medicine and Health

1998                         Sleep Research Society Award for Sleep Workshop: Molecular and Cellular Foundations of Sleep Disorders, LA, CA.

1997                         Sleep Research Society Award for Sleep Workshop; Molecular Biological Studies of Sleep, Program for Basic Sleep Research, LA, CA.

1995                         Fulbright Fellowship - Research/Lecturing Award from U.S. - Norway Fulbright Foundation, for research at Department of Psychiatry, Harvard University

1995                         US-Norway Foundation; Scandinavia Scholarship Award

1995                        Research Council of Norway, Division of Medicine and Health

1995                                      Sleep Research Society's travel fellowship for the World Federation of Sleep

                                Research Society's International Conference

1993                                      Sleep Research Society's travel fellowship for the World Federation of Sleep

1994                                      Research Society's International Conference on the Cellular Consequences of Sleep

1991                                      Nordic Academy for Advanced Study, Award for One month at Department of

                                Pharmacology, Karolinska Institutet, Karolinska Sjukhuset, Stockholm invited by

Professor Urban Ungerstedt

1992                         European Sleep Research Society's Congress Grant

1988                         The Royal Ministry of Administration and Consumer Affair, Norway

1985                         European Training Program grant, European Science Foundation

 

Editorial assignments in professional journals

1997-          Reviewer for Sleep Research Online

2003         Ad hoc reviewer in Psychopharmacology

2006         Ad hoc reviewer in Brain Research Bulletin

2007         Reviewer for Bioingeniøren, Norwegian Biomedical Scientific Journal

 

Lectures - international

1992 Spinale mekanismar i deaktivering og søvn. Antidepressivas verknad på frisetting av serotonin målt med mikrodialyse. Nordisk seminar. Smertegruppa ved Fysiologisk institutt,

UiB og ASTRA Pain Control AB. Universitetet i Bergen, Noreg (Nordic Seminar, norwegian)

1995 Spinal modulation of ascending sensory information: Effects in sleep and waking. Symposieinnlegg World Federation of Sleep Research Societies,

Second International Congress, Nassau, Bahamas

1995 Modulatory role of the descending serotonergic system in sleep and waking. Symposieinnlegg, The structure and function of the spinal cord, Nordic Network in Neurostereology. University of Bergen, Norway

1996 Simultaneous recording of sleep-wake stages, and alteration in brain neurotransmitters during sleep and wakefulness, measured by the microdialysis method.  

Woodstock Academy, Department of Psychology, Woodstock, Connecticut, U.S.A.

1997 The serotonergic system and behavior: changes related to sleep-wake states and depression.

Harvard University, Harvard Medical School, Neuroscience Basics of Psychopharmacology, course lecture for M.Ds in last year recidency, psychiatry.

1997 Modulatory role of the descending serotonergic system in sleep and waking. Muntlig presentasjon.

Nordic Sleep Congress, Scandinavian Societies for Sleep Research, Bergen, Norway

1997 Serotonin and GABA inhibit dorsal raphe nucleus and increase REM sleep as revealed by microdialysis. Nordic Sleep Congress, Scandinavian Societies for Sleep Research,

 Bergen, Norway

1997 A microdialysis study of neurotransmittors/neuromodulators regulating dorsal raphe nucleus activity:

serotonin, GABA, and adenosine.

Multi-Site Training Program for Basic Sleep Research by Sleep Research Society (US); Critical Analysis of The Role of Molecular Biology in Sleep Research at UCLA Lake

Arrowhead Conference Center, LA,CA, USA.

1997 A microdialysis study of neurotransmittors/neuromodulators regulating dorsal raphe nucleus activity: serotonin, GABA, and adenosine. In vivo Microdialysis in The Central

 Nervous System in Animals and Humans. International meeting Sleep Research Laboratory, Department of Physiology, University of Bergen, Norway

1999 Raphe nuclei and the ventrolateral preoptic nucleus. Multisite SCORE-NIH grant-group meeting, Harvard Medical School, Harvard University.Invited

1999 Basic regulatory mechanisms of the serotonergic system in sleep and depression. Conference sponsored by Sleep Disorders Division at Brigham and and Women’s Hospital, Boston, USA Invited

1999 Basic Sleep Research - Glimpse of Past Present and Future.

Sleep-Wake Disorders Canada (SWDC) - Ottawa-Hull Chapters Capital Sleep Conference, Ottawa, Canada

2007 Differentially Expressed Proteins after Sleep Deprivation, Nordic Sleep Meeting, Scandinavian Societies for Sleep Research, Bergen, Norway,

2008 Human Serum Protein Profile after Sleep Restriction, Chaired and organized symposium and talk at the 19th Congress of the European Sleep Research Society, Glasgow, UK

2009 Human Serum Protein Profile and Protein Identification after Sleep Restriction, talk, Norwegian National Proteomic Meeting, Bergen, Norway.

 

Invited Keynote speaker

2001 Raphe nuclei and the ventrolateral preoptic nuclei, University of Sao Paulo, Brasil, Invited

2001 World Federation of Sleep Research Societies, 4rd International Meeting, October 21-26, Punta del Este, Uruguay, Invited as Symposium speaker

2001 Søvn og biologiske rytmer, Navalmedisin, Sjøkrigsskolen, Håkonsvern, Bergen

2002 Basic Sleep Research - Glimpse of Latest Hot News and Future Bio Med Camp, Haukeland sykehus, Unge Forskere, August, Universitetet i Bergen, I

2002 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2002 Normal søvnfysiologi hos barn og voksne, Norsk Epilepsiselskap, Kristiansand, I

2003 Søvn og biologiske rytmer, Radiologisk seksjon, Kirurgisk institutt, Haukeland Universitetssykehus, Bergen, I

2003 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2003 Søvn hos barn og unge, Lysekloster barneskule, Bergen

2004 Statoil, konferanse om skiftarbeid og helse, Oslo, I

2004 Sleep, Alertness and Fatigue, Education in Recidency by American Academy of Sleep Medicine, Radiologisk seksjon, Kirurgisk institutt, Haukeland Universitetssykehus, Bergen, I

2004 NOPEF, HMS-konferanse, Søvn, skiftarbeid og helse, Stavanger, I

2004 Skiftarbeid og ulykker, Temaseminar HMS Petroleum, UiB/Unifob, Bergen, I

2004 Sleep, Alertness and Fatigue, Education in Recidency by American Academy of Sleep Medicine, Anestesileger, Kirurgisk institutt, Haukeland Universitetssykehus, Bergen, I

2004 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2005 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I

2005 Turnusarbeid – Søvn og biologiske rytmer, Kurs, Bioingeniørfaglig institutt, Lokal fagkomite i Bergen, I

2006 Sleep, Alertness and Fatigue in Health Care Settings,  Bioingeniørfaglig institutt, Bergen I, 22.02.06

2006 Nyere forskning og diagnostikk - bruk av molekylærbiologiske teknikker, MOL 100, Universitetet i Bergen 24.04.06

2006 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I, 04.05.06

2006 Søvn, skiftarbeid og uønskede hendelser, Olje og Anleggskonferanse, EL og IT-forbundet, Bergen Kongressenter, I, 28.09.06

2006 Søvn og biologiske rytmer, Sjøfartsmedisin, Sjøkrigsskolen, Håkonsvern, Bergen, I, 26.10.06

2007 Sleep deprivation, stress and cellular stress measured by proteomics, Oxford University, Invited by Prof. Russell Foster, scheduled medio March 2007, postponed

 

Research Interests:

Genomics and proteomics, stress, cellular stress, sleep mechanisms, sleep deprivation, shift-work, depressive and neurodegenerative disorders.

 

Professional Memberships:

1997-                        Sleep Research Society

1996-                        Society for Neuroscience

1993-                        Scandinavian Society for Sleep Research

1992-                        European Sleep Research Society

1986                         European Neuroscience Association

1985                         Norwegian Physiological Society

1985                         Scandinavian Physiological Society                               

 

Research techniques (see references in PubMed for all techniques used, only listed last 5 years here):

Proteomics and genomics – applied techniques (supervisor):

PCR, gel-running, Western-, Northern-blot, ELISA, SELDI-Tof-MS, MALDI- and Q-Tof-MS, MS/MS

Course experience:

Gene technology:         Purification of DNA and RNA agarose-gel electrophoresis and isotope labeling of probes. Gene expression in prokaryotes and eukaryote. Isolating DNA and RNA, isolating RNA by phenol chloroform extraction. Isolation of plasmid DNA and bacteriophage lambda DNA. Construction and screening of genom library. DNA sequencing (Sanger’s methods). Southern, Northern and Western blotting     

 

Publications

A Original scientific publications with referee (total 19)

 

1Bjørkum, A.A. and Berge, O.-G. The relative contribution of ascending and descending serotonergic pathways in p-chloro­amphetamine induced antinociception. Pharm. Biochem. Behavior, 1988, 31; 135-140

2Bjørkum, A.A., B. Bjorvatn, D. Neckelmann and R. Ursin. Sleep effects following intrathecal administration of the 5-HT1A agonist 8-OH-DPAT and the NMDA antagonist AP-5 in rats. Brain Res. 1995, 692; 251-258.

3Bjørkum, A.A., Neckelmann, D., Bjorvatn, B. and Ursin R. Lesion of descending serotonergic pathways increases zimeldine-induced waking in rats. Physiology and Behav. 1995, 57; 959-966.

4Bjorvatn, B., A.A. Bjørkum, D, Neckelmann and R. Ursin. Sleep/waking and EEG power spectrum effects of a non-selective 5-HT antagonist and a selective 5-HT reuptake inhibitor given alone and in combination. Sleep, 1995, 451-462.

5Neckelmann, D., Bjørkum A.A., Bjorvatn, B., Ursin R. Sleep and EEG power spectrum effects of the 5-HT1A antagonist NAN-190 alone and in combination with citalopram. Behav. Brain Res., 1996, 75; 159-168.

6Bjørkum, A.A. and Ursin, R. Sleep/waking effects following intrathecal administration of the 5-HT1A agonist 8-OH-DPAT alone and in combination with the 5-HT1A antagonist NAN-190. Brain Res. Bull. 1996, 39; 373-379.

7Bjorvatn, B., D., Neckelmann, A.A. Bjørkum and R. Ursin. Hypothermia and 5-HT syndrome induced by CGS 12066B independently of 5‑HT1B receptor activation. Behav. Pharmacol. 1996, 7 (5): 462-469.

8Neckelmann D., Bjorvatn B., Bjørkum, A.A., Ursin R. Citalopram: differential sleep/wake and EEG power spectrum effects after single dose and chronic administration. Behav. Brain Res., 1996, 79 (1-2), 183-192.

9Porkka-Heiskanen, T., Strecker, R.E., Thakkar, M., Bjørkum, A.A., Green, R. W.  and McCarley R.W. Adenosine; A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness, Science, 1997, 276, (5316), iss. of 23 May, pp. 1265-1268.

10Strecker, R.E., Thakkar, M.M., Porkka-Heiskanen, T., Dauphin, L.J., Bjørkum, A.A. and McCarley R.W. Behavioral state-related changes of extracellular serotonin consentration in the pedunculopontine tegmental nucleus: A microdialysis study in freely moving animals. Sleep Research Online 2(2): 21‑27, 1999.

11Sørensen, E., Grønli, J., Bjorvatn, B., Bjørkum, A.A. and Ursin, R. Sleep and waking following microdialysis perfusion of the selective 5-HT1A antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat . Brain Res. 2001, 897; 122-130.

12 Chou, T, Bjørkum, AA., Lu, J., Scammell, T. and Saper, C.B.; Afferents to the ventrolateral preoptic nucleus.

J Neurosci. 2002 Feb 1;22(3):977-990.

13Lu, J., Bjørkum, A.A., Xu, M., Gaus, S.E., Shiromani, P. and Saper, C.B.; Selective Activation of the Extended Ventrolateral Preoptic Nucleus during Rapid Eye Movement Sleep. J Neurosci. 2002 Jun 1;22(11): 4568-4576.

14Bjorvatn, B, Grønli , J, Hamre, F, Sørensen, E, Fiske, E, Bjørkum, A.A., Portas, C.M, and Ursin, R. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Neuroscience. 2002;113(2):323-30.

15 Bjorkum, A. A., Strecker, R.E., Portas C.M.,  Porkka-Heiskanen, T., Thakkar M. and McCarley R.W. Perfusion of a 5-HT1A antagonist in the cat dorsal raphe nucleus increases extracellular serotonin and wakefulness, Sleep Research Online, 2003, 5(4): 149-154.

http://www.sro.org/bin/article.dll?Paper&2547&0&0

16 Kristensen , T., Nybø, R., Bjørkum, A.A., Decision Trees Identifying Changes in Proteome Expression

Induced by Sleep Deprivation, Proceedings of ESM, 2005:262-269 (EUROSITIS-ETI Publication ISBN-90-77381-22-8).

17 Fiske E, Portas CM, Grønli J, Sørensen E, Bjorvatn B, Bjørkum AA, Ursin R. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta Physiol (Oxf). 2008 May;193(1):89-97. Epub 2007 Dec 14.

18 Shea JL, Mochizuki T, Sagvaag V, Aspevik T, Bjorkum AA, Datta S. Rapid eye movement (REM) sleep homeostatic regulatory processes in the rat: changes in the sleep-wake stages and electroencephalographic power spectra. Brain Res. 2008 Jun 5;1213:48-56. Epub 2008 Apr 7.

19. Eszter Takács *, Rita Nyilas *, Zsuzsanna Szepesi *, Péter Baracskay*, Bente Karlsen† , Tina Rosvold†, Alvhild A. Bjørkum†, András Czurkó *, Adrienna K. Kékesi *, Gábor Juhász. Seizure Related Expression of Matrix Metalloproteinases without Tissue Damage. Neurochem Int. 2010 May-Jun;56(6-7):799-809. Epub 2010 Mar 18

 

B Manuscripts accepted/submitted/in preparation (6 in preparation)

1. Bjorkum A.A., Rosendahl, K., Braseth, T., Nygard, I., Gurvin, I., Kristensen, T., Nybo, R., Bjørnstad, A., Kluge B. Short term sleep deprivation  reduce Heat Shock Protein 70 in human blood serum (manuscript).

2. Bjorkum A.A., Gurvin, I., Nygard, I., Braseth, T., Kluge, B., Rosendahl, K.. Short term sleep deprivation reduce SIgA in human saliva (manuscript).

3..Bjorkum A.A., Kluge, B., Nygard, I., Braseth, T., Gurvin, I., Kristensen, T., Nybo, R., Berven F., Rosendahl, K.  Specific Proteome Expression Changes in Human Blood Serum after Short Term Sleep Deprivation (manuscript).

4. Bjorkum AA., Kluge B., Myhre, C., Kjaerstad S, Kristensen, T., Nybo, R., Berven F., Rosendahl, K.

Specific Proteome Expression Changes in Human Blood Serum after MR-procedure in children (manuscript)

5. Bjorkum AA., Kluge B., Myhre, C., Kjaerstad S, Kristensen, T, Holdhus R, Breilid H., Steen V.M.*. Rosendahl, K.

Specific Genome Expression Changes in Human Blood Serum after MR-procedure in children (manuscript)

6. Eszter Takács *, Rita Nyilas *, Zsuzsanna Szepesi *, Péter Baracskay*, Bente Karlsen† , Tina Rosvold†, Alvhild A. Bjørkum†, András Czurkó *, Adrienna K. Kékesi *, Gábor Juhász. Seizure Related Expression of Matrix Metalloproteinases without Tissue Damage (accepted, Journal of Neurochemistry International, March 2010). 

 

Reviews, bookchapters, synopsis (4)

1McCarley RW, Strecker, RE, Porkka-Heiskanen, T, Thakkar, M, Bjørkum, AA, Portas, CM, Rainnie, DG and Greene, RW. Modulation of cholinergic neurons by serotonin and adenosine in the control of REM and Non-REM sleep. In Hayaishi O and Inoué S, eds. Sleep and Sleep Disorders:From Molecule to Behavior. Tokyo: Academic Press/Harcourt Brace Japan, 1997, pp 63‑79.

2Ursin, R., Bjorvatn, B., Sommerfelt, L., Neckelmann, D. and Bjørkum, A. A. Studies on sleep-waking effects of serotonin reuptake inhibitors and receptor subtype involvement. Journal of Sleep Research, 1992, 1, 157-162.

3 Bjørkum, A.A. , Pallesen, S. Holsten, F, Bjorvatn, B. Skiftarbeid og  ulykker – relevans for offshoreindustrien, Tidsskr Nor Lægeforen, 2004; 124(21):2773-5, review.

4 Pallesen, S. Holsten, F,  Bjørkum,A.A. , Bjorvatn, B. Søvnvansker ved nattarbeid, et problem for offshoreindustrien? Tidsskr Nor Lægeforen , 2004; 124(21):2770-2, review.

 

Abstracts not published otherwise (19 out of total 45)

1 Fiske, E., Grønli , J, Hamre, F, Bjørkum, A.A., Portas, C.M, and Ursin, R. Investigation of the effect of bicuculline perfused in DRN on sleep, waking and 5-HT levels in the DRN and FC. Submitted abstract to the 16th Congress of the European Sleep Research Society, June 3-7, 2002.

2 Fiske E, Gronli J, Hamre F, Bjorkum AA, Portas CM, Ursin R Effect of bicuculline perfused in DRN on 5-HT levels in the DRN and FC. Sleep 26: A17-A17 May 15 2003.

3 A.A. Bjorkum, T.T. Kanhema. CHANGE IN THE GENOME AND THE PROTEOME AFTER SLEEP DEPRIVATION. Program No. 965.7. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online.

4 A.A. Bjorkum, K. Rosendahl, S.K. Alvsvaag, E. Stange, H. Åarseth, Å.M. Lien, M.A. Hashmi, T. Kanhema, A.Bjørnstad, B. Kluge, and F.L. Daae.  Proteome expression after sleep deprivation. An international meeting in honor of Michel Jouvet: “The paradox of sleep: an unfinished story”,Lyon, 2003

5 A.A. Bjorkum, K. Rosendahl , S.K. Alvsvaag, E. Stange, H. Åarseth, Å.M. Lien, M.A. Hashmi, T. Kanhema, F.L. Daae, B. Kluge, and A. Bjørnstad. Sleep deprivation - consequences for proteome expression. Accepted abstract to the 17th Congress of the European Sleep Research Society, 2004, J. Sleep. Res. 2004, 13,s1;76

6 A.A. Bjorkum, K. Rosendahl, H.B. Ingebrigtsen, H. Kolstad, I.M. Myhr, S.K. Alvsvaag, E. Stange, T. Kanhema, B. Kluge, and A. Bjørnstad. Sleep deprivation changes proteome expression. APSS 19th Annual Meeting. A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society, Accociated Professional Sleep Society (APSS) Denver, Colorado, USA, June 18-23, 2005, Sleep, 28: A153-A153, 2005

7 AA Bjørkum, C Helgesen, O Ging, P Shiel, B Kluge, C Myhre, S Kjaerstad and K Rosendahl, Cellular response to MR-procedure,  Benzonsymposium nr. 52, Cellular responses to DNA damage, Copenhagen 21-25,2005, accepted*.

8. A.A. Bjorkum, K. Rosendahl, I. Holm, M. Kirkevoll, AC Kroksveen, EK Sæterdal, T. Kristensen, R Nybø,T. Kanhema, B. Kluge, and A. Bjørnstad Proteome Expression Changes in Human Blood Serum after Sleep Deprivation by a Decision Tree Classification Method, New Delhi, India, Interim Congress of World Federation of Sleep Research and Sleep Medicine Societies (WFSRSMS), 22-26 September, 2005, accepted*.

9. Bjorkum, A.A., Rosendahl, K., Aarhus Braseth, T., Nygard,I., Gurvin, I., Kristensen, T., Nybo, R. Differential Expression Proteomics after Sleep Deprivation, European Sleep Research Society, 18th Congress of the European Sleep Research Society, September 12-16, 2006. , J. Sleep. Res. 2006, 16, s239; P501.

10. A.A. Bjorkum, B. Kluge, T. Aarhus Braseth, I. Gurvin, T. Kristensen, R Nybo, K. Rosendahl, I. Nygaard. Changed Protein Profile after Sleep Restriction, World Sleep 2007, Cairns, Australia, Sleep and Biological Rhythms 2007; 5: A91, PO310

11. A.A. Bjorkum, I. B. Kluge, I Nygaard, T. Aarhus Braseth, I. Gurvin, T. Kristensen, R Nybo, K. Rosendahl. Differentially expressed proteins after sleep deprivation including serum Hsp-70 and saliva IgA. Neuroscience, San Diego, USA, 2007, 735.3.

12. S. SAHA1, V. SAGVAAG2, T. ASPEVIK2, R. R. MACLEAN3, A. A. BJØRKUM2, S. DATTA3, Homeostatic regulation of rapid eye movement (REM) sleep involves increased delta- and decreased theta-frequency wave activities in the cortical electroencephalogram, Neuroscience, San Diego, USA, 2007, 632.4.

12.  Bjørkum A, Kluge B, Kjærstad S, Rosendahl K, Genomic change after routine 3T MRI in children, A pilot study. O47, Pediatr Radiol (2008) 38 (Suppl 3):S619–S624 (Europ. Radiol møte oral pres – best score Edinburg 2008.)

13 A.A. Bjorkum*1, I. Nygaard1, T. Aarhus Braseth1, I. Gurvin1, T. Kristensen2,, R Nybo2,, K. Rosendahl 3, B. Kluge 4., Human Serum Protein Profile after Sleep Restriction., Journal of Sleep Research, Volume 17 Issue s1, S08, Pages 1 - 282 (December 2008), Special Issue: Abstracts of the 19th Congress of the European Sleep Research Society, 9-13 September 2008, Glasgow, UK

14. Bjørkum AA, Kluge B, Myhre C, Kjaerstad S, Rosendahl K. Proteomic and Genomic Changes after Routine Magnetic Resonance Imaging (MRI) in Children. A Pilot Study.  Bergen University College,  Great Ormond Street Hospital and Institute for Surgical Sciences, University of Bergen, Poster  Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

15. A.A. Bjørkum*1, T. Aarhus Braseth1, I. Nygaard1, I. Gurvin1, T. Kristensen2, R. Nybo2, B. Kluge3, K. Rosendahl4. Human Serum Protein Profile and Protein Identification after Sleep Restriction, talk, Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

16. Terje Kristensen, Vemund Jakobsen and Alvhild A. Bjørkum. Computational Proteomics – A Pattern Solutions Approach. Poster, Norwegian National Proteomic Meeting, Bergen, 26-27 October 2009.

17. TERJE  KRISTENSEN, VEMUND JAKOBSEN, ALVHILD ALETTE BJØRKUM, Different Visualization

Schemes of Protein Data Clustering. FOURTEENTH INTERNATIONAL CONFERENCE

ON COGNITIVE AND NEURAL SYSTEMS. Boston 19-22 May, 2010, accepted.

18. Protein Identification of Changed Protein Levels by Proteomics after Sleep Restriction

A.A. Bjørkum*1,T.  Gurvin1, T. Aarhus Braseth1, I. Nygaard1, I.,T. Kristensen1, R., B. Kluge2, K. Rosendahl3

20th Congress of the European Sleep Research Society, Lisboa 2010, accepted.

19.Protein Identification and Changed Levels by Proteomics after Sleep Deprivation,

A.A. Bjørkum*1,T.  Gurvin1, T. Aarhus Braseth1, I. Nygaard1and K. Rosendahl2, SLEEP 2010 24th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS), June 5- 9, 2010, San Antonio, Texas, USA, submitted

 

 

G. Other publications

 

Other publications 23 Supervised main Projects at Bergen University College (BUC), Biomedical Laboratory Sciences Program and collaborative institutions as Harvard University and other collaborative institutions.

1. Bratland, E., Kristoffersen G., Sørhus E. Nevronal aktivitet i søvn-og våkentaktivt relaterte nevriner. Kan immunohistokjemisk merking av proteinet c-Fos gi oss informasjon om søvn og våkenaktive nerveceller i hjernen? BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2002, Marked 2.1

2. Agledal, L. Determining cyclic AMP in rat cortical neuronal cultures using high performance liquid chromatography and enzyme immunoassay. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2003, Grade: A

3. Alvsvåg, SK., Stange, E. Proteinekspresjon etter søvndeprivasjon. BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2003, Grade: B

4. Skartland, LK, Sund, N. Immunohistochemistry as a Method to detect Cholinergic Neurons in Basal Forebrain. The Effect of Sleep Deprivation on the Expression of Hsp72(i). BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Psychiatry, Harvard University and VA Boston Heathcare System West Roxbury, Boston, USA, 2003, Grade: A

5. Aarset, H, Lien ÅM, Hashmi. Genekspresjon av hydrogenperoksidase og Hsp 70 ved søvndeprivasjon. BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2003, Grade: B

6. Ingebrigtsen,HB, Kolstad, H, Myhr, IM. Reduksjon i heat shock protein 70 i humant serum etter søvndeprivasjon målt med en ELISA metode. BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2004, Grade: A

7. Lomheim IJ, Rasmussen, E, Myhre, C, Lied Belt, B. Preanalytiske forhold ved proteomiske analyser. BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2004, Grade: B

8. Brattaas, M. Changes in small intracellular proteins and peptides in physiologically and neurochemically controlled epileptic cellular stress in rat cortex. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2004., Grade: 11 (corresponds to A).

9. Holm, I, Kirkevoll, M, Kroksveen, AC, Sætersdal, EK., BUC, Proteomiske analyser ved cellulært stress. Biomedical Laboratory Sciences Program, Bergen, NO, 2005, Grade: B

10. Sleire, L, Karlesn I.F. The Role of GABAergic (non-cholinergic) Neurons In Basal Forebrain Involved in Activation of the Cerebral Cortex, BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard Medical School, Harvard University, Boston, USA, 2005, Grade: A.

11. Fimland, A.E., Gustad, A-K., Tangenes Os, I., Olsvik, M. Proteomisk analyse etter MR-undersøking av born. BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2006, Grade: A

12. Øines, E., Ofte ML., Sleep Deprivation-Induced Changes in the Synaptic Proteins in Rat Hippocampus. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard Medical School, Harvard University, Boston, USA, 2006, Grade: A.

13. Karlsen, B., Rosvold, T.C., Induction of MMP9 in Absence Epileptic Rats. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2006., Grade: A.

14. Padøy, T., Haugland, G.,Magnussen, G. Endring av immunglobulin A i humant saliva ved lett søvndeprivasjon målt med ELISA metode. Biomedical Laboratory Sciences Program, Bergen, NO, 2007, Grade: B

15. Haukeland, M.L., Klungtveit, N, Bru, S., Jensen, H.S., Effekter av hypoksisk stress på laks. Biomedical Laboratory Sciences Program, Bergen, NO, 2007, Grade: passed (changed from marks to pass/non-pass in 2007).

16. Aspevik, T., Sagvaag, V., Electrophysiological Signs of Rapid Eye Movement Homeostasis. Sleep Research Laboratory, Dept. of Psychiatry, Boston University School of Medicine, Boston University, Boston, USA, 2007., Grade: A with distinction/passed.

17. Myrlien, A., Johnsen, M., Comparative Proteomics of Sleep Deprived Anxiety Model Mice. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Department of Physiology and Neurobiology, MTA-ELTE Research Group of Neurobiology, Hungary, 2007., Grade: A/passed.

18. Myrmel, SL., Varnes, BK., Nilsen-Nygaard, J., Endring av alpha-amylaseaktivitet i humant saliva etter lett søvndeprivasjon. ? BUC, Biomedical Laboratory Sciences Program, Bergen, NO, 2008,  passed.

19. Kornberg, G., Tveiten, H., How does Sleep Deprivation and Recovery Sleep Affect Proteins that regulate Synaptic Plasticity? BUC, Biomedical Laboratory Sciences Program, Bergen, NO and SRI International Bioscience Division, San Francisco, USA, 2008, passed.

 20. Busk, S.A., Skogland, K., Inflammation and Sleep. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2009.

21.Grebstad Lødøen, L., Dysvik, R. ER proteins from hypothalamus undergo more oxidative damage in aged then in young mice then the proteins in general. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and University of Pennsylvania School of medicine, Center for Sleep and Respiratory Neurobiology, Pennsylvania, USA, 2009.

22.Markussen, C. Sleep deprivation and long term  molecular tuning of brain cells. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Eötvös Loránd University, Institute of Biology, Proteomics Laboratory, Budapest, Hungary, 2009.

23.Skartveit, L., Hovland, M. Homeostatic regulation of sleep: The role of VLPO. BUC, Biomedical Laboratory Sciences Program, Bergen, NO and Dept. of Neurology, Harvard University and Children's Hospital, Boston, USA, 2009.

 

 

Other publications 2

1. Daae FL, Bjørkum AA. Innføring i DNA teknologi for bioingeniører, våren 2003. Ekstraksjon av DNA, Elektroforese, PCR, Restriksjon, Sekvensering. HiB-publikasjon 2003

2. Daae FL, Bjørkum AA. Innføring i DNA teknologi for bioingeniører, Ekstraksjon av DNA, Elektroforese, PCR, Restriksjon, Sekvensering. våren 2004, ISBN 82-513-0026-6

3. Salinas I. and Bjørkum AA. Histology journal, 2007.